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肺癌干细胞标志物的研究进展 被引量:2

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摘要 近年来,肺癌由于发病率和病死率居高不下,已经成为各种恶性肿瘤中致死的主要原因之一/[1/],对人类健康和生命造成了严重损害。肺癌其治疗难点表现为肿瘤耐药、复发和转移,尽管人们对于肺癌治疗方式的不断探索,其5年生存率仍徘徊在15%左右/[2/]。基于肿瘤干细胞的假说,肺癌干细胞可能为肺癌的起源细胞,在肺癌的复发、转移及耐药方面发挥着重要作用。对于肺癌干细胞标记物的研究将有助于肺癌干细胞的分离及鉴定,
出处 《中华肺部疾病杂志(电子版)》 CAS 2015年第5期82-85,共4页 Chinese Journal of Lung Diseases(Electronic Edition)
基金 国家自然科学基金(81302016)
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  • 1Allen RA;Lisa JR.Combined liver cell and bile duct carcinoma,1949.
  • 2Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin, 2013, 63(1): 11-30.
  • 3Adachi K, Suemori H, Yasuda SY, et al. Role of SOX2 in maintaining pluripotency of human embryonic stem cells. Genes Cells, 2010, 15(5): 455-470.
  • 4Wang Z, Oron E, Nelson B, et al. Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell, 2012, 10(4): 440-454.
  • 5Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature, 2007, 448(7151): 313-317.
  • 6Drilon A, Rekhtman N, Ladanyi M, et al. Squamous-cell carcinomas of the lung: emerging biologyj controversies, and the promise of targeted therapy. Lancet Oncol, 2012, 13(10): e418-e426.
  • 7Sholl LM, Barletta JA, Yeap BY, et al. Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma. Am J Surg Pathol, 2010, 34(8): 1193-1198.
  • 8Cai YR, Zhang HQj Zhang ZD, et al. Detection of MET and SOX2 amplification by quantitative real-time PCR in non-small cell lung carcinoma. Oncol Lett, 2011, 2(2): 257-264.
  • 9Nakatsugawa M, Takahashi A, Hirohashi Y, et al. SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. Lab Invest, 2011, 91(12): 1796-1804.
  • 10Maddison P, Thorpe A, Silcocks P, et al. Autoimmunity to SOX2, clinical phenotype and survival in patients with small-cell lung cancer. Lung Cancer, 2010, 70(3): 335-339.

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