完全切除的非小细胞肺癌脑转移危险因素分析

The Risk Factors of Brain Metastases in Non- small Cell Lung Cancer Patients after Complete Resection

目的分析完全切除非小细胞肺癌脑转移的危险因素.方法回顾性分析214例经病理确诊、手术完全切除的非小细胞肺癌患者资料,其中发生脑转移者53例,未发生脑转移者161例,用log-rank检验对脑转移患者的临床资料进行单因素分析,当2个变量显著相关时,用cox回归模型多因素分析与脑转移最相关的变量.结果单因素分析显示,年龄、病理类型、T分期、N分期、辅助化疗是非小细胞肺癌发生脑转移的可能危险因素.多因素分析显示,病理类型、N分期是非小细胞肺癌发生脑转移的高危因素.结论非鳞状细胞癌、N2-3期是非小细胞肺癌发生脑转移的独立危险因素.

Objective To analyze the risk factors of brain metastases in non- small cell lung cancer（NSCLC） patients after complete resection of cancer.Methods We retrospectively analyzed the clinical data of214 patients with pathologically confirmed non- small cell lung cancer who received complete resection of cancer.Among the 214 NSCLC patients, there were 53 cases with brain metastases and 161 without brain metastases.Log- rank test was used to give a single factor analysis of the clinical data of patients.If two variables were correlated, cox regression model was used to give a multiple factor analysis of the most correlated factors of brain metastases.Results Single factor analysis showed that the age, pathological types, T staging, N staging and adjuvant chemotherapy were the possible risk factors of brain metastases in non- small cell lung cancer patients.Multiple factor analysis showed that the pathological types and N staging were the high risk factors of brain metastases in non- small cell lung cancer patients.Conclusion Non- squamous cell cancer and N2- 3 stage are independent risk factors of brain metastases in non- small cell lung cancer patients.