一种无伪影小动物头部成像固定装置的设计

Design of artifact-free head holder for small animal imaging

目的:设计一种无伪影的动物头部成像固定装置,以有效解决因位移所造成的伪影。方法:仿照啮齿动物的头部立体定位仪,在普通车床上利用轻质易成型材料聚甲基丙烯酸甲酯,设计并制作简单易操作的小动物头部成像固定装置。结果:将所设计的装置在小动物PET-CT成像设备中试用,可有效解决头部摆位不正和微小的位移所造成的伪影,克服了将检查对象置于检查野正中难度大且易造成呼吸抑制等问题。结论:小动物头部成像固定装置的设计克服了现有检查床在动物固定方面的不足,其结构简单、操作方便,值得推广应用。

Objective：To design a kind of head holder for small animal imaging without artifact. Methods： The head holder was designed for small animal imaging according to rodent head stereotaxic apparatus with lightweight and easy molding material （polymethyl methacrylate）. The holder can be easily made with ordinary lathe and can be easily operated in small animal imaging device. Results：After the trial in small animal PET-CT, the holder can effectively solve the problems in small animal imaging such as the artifact caused by tiny displacement, tilt head position, deviating from the central field of view and respiratory depression. Conclusion： The small animal imaging device was designed in simple structure to overcome the shortcomings of the existing technology. The operation of the device is simple, which is worthy of popularization head holder of application.