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顶空气相色谱法测定阿哌沙班原料药中有机残留溶剂的残留量 被引量:1

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摘要 目的:建立了测定阿哌沙班原料药中的甲醇、乙醇、丙酮、二氯甲烷、乙酸乙酯、正丁醇、吡啶、甲苯、N,N-二甲基甲酰胺(DMF)含量的顶空气相色谱法:采用DB-624毛细管柱(30.0 m×0.53 mm,3.00μm)(6%氰丙基苯-94%二甲基硅氧烷共聚物),氢火焰离子化检测器(FID),程序升温,进样口温度220℃,检测器温度250℃,分流进样模式,测定残留溶剂的含量。结果:9种残留溶剂在各自的浓度范围内具有良好的线性关系(相关系数均为0.999以上),回收率符合规定。结论:本方法专属性强,操作简便,结果可靠,可用于9种残留溶剂的同时测定。
出处 《天津药学》 2015年第5期24-26,共3页 Tianjin Pharmacy
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