调控药用植物药效成分合成的转录因子研究进展

Advances in studies on transcriptional factor regulation of biosynthesis of active components in medicinal plants

大多药用植物的药效成分为植物本身的次生代谢产物,包括生物碱、萜类、类黄酮、酚类、苷类等。植物体内及体外环境条件会影响这些次生代谢产物的合成,导致其合成量的增加或减少,或是影响同类代谢产物不同单体成分的合成与否及合成量。目前所知调控次生代谢产物合成的机制有转录调控、转录后调控等多种形式,其中转录调控研究较多。综述了药用植物类黄酮、生物碱、萜类等活性成分生物合成相关的转录因子研究进展,为利用转录调控控制和提高药用植物药效成分合成的研究与应用提供借鉴。

Most of active ingredients from medicinal plants are secondary metabolites including alkaloids, terpenoids, flavonoids, phenols, glycosides, and so on. The biosynthesis of secondary metabolites is not only determined by the plant internal factors but also influenced by the environmental factors, leading to the variation of synthetic quantity and the metabolite monomer composition. At present, transcriptional and post-transcriptional regulations have been found in the biosynthesis of secondary metabolites. More advances were achieved in transcriptional regulation. The paper reviews the progress obtained in the researches on transcription factors regulation of the biosynthesis of flavonoids, alkaloids, terpenoids, and other active ingredients from medicinal plants, which will be useful for further studies on the biosynthetic regulation of the active ingredients in medicinal plants.