胃癌组织中乳腺癌转移抑制基因1的表达及其临床意义

Expression of breast cancer metastasis suppressor 1 in gastric carcinoma and relevant clinical significance

目的:探讨乳腺癌转移抑制基因1(BRMS1)蛋白在胃癌组织中的表达及其临床意义。方法:采用免疫组织化学法检测60例胃癌组织及相应癌旁组织60例中BRMS1蛋白的表达情况,并分析其与各临床病理特征之间的关系。结果:在胃癌组织中BRMS1蛋白低表达(35.0%),在癌旁组织中高表达(75.0%),差异有统计学意义(P<0.01);胃癌组织中BRMS1的表达水平在胃癌患者组织分化程度、淋巴结转移和临床分期间差异均有统计学意义(P<0.01),而在患者性别、年龄、浸润深度和肿瘤大小间差异均无统计学意义(P>0.05)。结论:BRMS1蛋白在胃癌组织中呈异常低表达,且其低表达可能与胃癌的发生、发展以及浸润转移有一定关系。

Objective：To investigate the expression of breast cancer metastasis suppressor 1（BRMS1） and its clinical significance in gastric carcinoma. Methods：The expression of BRMS1 in gastric carcinoma tissues（n=60） and para-cancerous tissues（n=60） was detected by immunohistochemiscal method. The relationship between the immunohistochemiscal results and the clinic pathologic parameters were analyzed. Results：The expression rate of BRMS1 in gastric carcinoma tissues（35. 0%）was significantly lower than that in para-cancerous tissues （ 75. 0%） （ P 〈0. 01 ）;there was the correlation between the expression of BRMS1 and the degree of differentiation,lymph node metastasis and clinical stages（P〈0. 01）,there was no correlation between the expression of BRMS1 and patient sex,age,infiltrative depth and size of tumor （P 〉0. 05）. Conclusions：The BRMS1 protein was lower-expression in gastric carcinoma,which may be related with the tumor genesis,invasion and metastasis of gastric carcinoma.