自体角膜缘干细胞移植术治疗翼状胬肉疗效观察

Effect of corneal limbal stem cells autotransplantation in the treatment of pterygium

目的:探讨自体角膜缘干细胞移植术治疗翼状胬肉的临床疗效。方法:选取84例(98眼)翼状胬肉患者,随机分为A、B 2组。A组42例(50眼)予以常规单纯翼状胬肉切除术治疗,B组42例(48眼)予以翼状胬肉切除联合自体角膜缘干细胞移植术治疗,比较2组患者术后复发率、治愈率、角膜创面上皮愈合时间及术后不良反应。结果:B组复发率4.2%,低于A组的20.0%(P<0.05),B组角膜创面上皮愈合时间(4.1±1.9)d,少于A组的(6.9±2.3)d(P<0.01);B组患者术后明显不适者2例(4.2%),少于A组的13例(26.0%)(P<0.01)。结论:翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉可有效提高治愈率并促进角膜创面上皮愈合,降低复发率,患者术后不良反应轻,值得临床应用推广。

Objective：To explore the clinical effects of the corneal limbal stem cells autotransplantation in the treatment of pterygium. Methods：Eighty-four cases（98 eyes） were randomly divided into the group A and group B（42 cases each group）. Group A（50 eyes） were treated with conventional peteryguim excision,group B（48 eyes） were treated with the pterygium excision combined with corneal limbal stem cells autotransplantation, respectively. The recurrence rate, healing rate, healing time of corneal epithelial wound and postoperative reactions between two groups were compared. Results：The recurrence rate in group B（4. 2%） was lower than that in group A（20. 0%）（P〈0. 05）. The healing time of corneal epithelial wound in group B[（4. 1 ±1. 9）d] was less than that in group A [（6. 9 ＆#177; 2. 3）d]（P〈0. 01）. The obviously postoperative discomfort in 2 cases of group B（4. 2%） was less than that in 13 cases of group A（26. 0%）（P〈0. 01）. Conclusions：The treatment of pterygium with conventional pterygium excision combined with corneal limbal stem cells autotransplantation can effectively reduce the recurrence rate,increase the healing rate,improve the corneal epithelial wound healing and reduce the postoperative reaction,which is worthy of clinical promotion and application.