CYP17基因多态性与新疆维、汉民族女性乳腺癌相关性研究

Correlation between CYP17 Gene Polymorphism and Breast Cancer of Uygur and Han Women in Xinjiang

目的探讨CYP17 rs743572位点基因多态性在新疆维、汉民族女性乳腺癌中的分布与乳腺癌易感性的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测130例维吾尔族女性乳腺癌患者、125例维吾尔族正常女性及120例汉族女性乳腺癌患者、118例汉族正常女性的CYP17 rs743572位点多态性,并分析该位点多态性与新疆维、汉民族女性乳腺癌易感性的关系。结果在病例组及对照组中,维、汉两民族基因型分布及等位基因频率具有显著差异(P<0.05);在维、汉族各亚组中,病例组与对照组的基因型分布差异及等位基因频率均无统计学差异(P>0.05);维、汉两民族病例组与对照组各基因型及等位基因均未增加患乳腺癌的风险。结论病例组、对照组中维、汉两民族基因型分布及等位基因频率具有显著差异。CYP17基因rs743572位点多态性与新疆维、汉民族女性乳腺癌的发生无明显相关。

Objective To investigate the relationship between CYP17 rs743572 gene polymorphism and breast cancer susceptivity in Uygur and Han women.Methods Using the polymerasechain reaction-restrictive fragment length polymorphism（PCR-RFLP） method to examine the CYP17 rs743572 position spot polymorphism from 130 cases of Uygur patients with breast cancer,125 cases of Uygur normal women,120 cases of Han patients with breast cancer,and 118 cases of Han normal women,and to analyze the relationship between polymorphism at this spot and susceptivity with breast cancer.Results In the 2 groups of the Uygur and Han,the genotype distribution and allele frequency had significant difference（P〈0.05）.There was no significant difference between genotype distribution and allele frequencies in both groups of the Uygur and Han（P〈0.05）; Genotype and allele didn＇t increase the risk of breast cancer for both groups of the Uygur and Han.Conclusion In the 2 groups of the Uigur and Han,the genotype distribution and allele frequency have significant difference.CYP17 rs743572 polymorphism is not related to breast cancer in both Uygur and Han groups.