血清SA、EA-IgA、VCA-IgA在鼻咽癌中表达及联合检测的临床意义

Clinical Significance of Serum Expression and Combined Detection of SA,EA-IgA and VCA-IgA in Nasopharyngeal Carcinoma

目的探讨鼻咽癌患者血清中唾液酸(SA)、EB病毒衣壳抗原免疫球蛋白A(VCA-Ig A)及早期抗原免疫球蛋白(EA-Ig A)的表达及联合检测对鼻咽癌的诊断意义。方法选择42例鼻咽癌患者作为研究对象,另外选取42例良性鼻炎患者、42例同期体检健康成人作为比较。采用ELISA法检测EA-Ig A、VCA-Ig A,酶法检测SA,比较3种检验方法的特异性及灵敏度。结果鼻咽癌患者SA、EA-Ig A、VCA-Ig A水平均高于正常人组及鼻炎组患者,差异具有统计学意义(P<0.05);单一指标阳性判断,SA、VCA-Ig A、EA-Ig A诊断鼻咽癌患者的灵敏度及特异性分别为30.95%和83.33%,76.19%和95.24%,57.14%和92.86%,VCA-Ig A灵敏度高于EA-Ig A;以两项及以上指标阳性联合检测,诊断鼻咽癌灵敏度及特异性为90.48%和92.86%。结论 SA、EA-Ig A、VCA-Ig A在鼻咽癌患者中表达水平升高,联合检测SA、EAIg A、VCA-Ig A对鼻咽癌患者诊断治疗具有重要临床意义,可筛查患者、监测临床治疗及评估预后。

Objective To investigate the clinical significance of serum expression and combined detection of SA,EA-Ig A and VCA-Ig A in nasopharyngeal carcinoma.Methods 84 patients with nasopharyngeal carcinoma were selected as research subjects,42 cases of benign rhinitis patients,and 42 cases of healthy adults were selected as the control group.The level of EA-Ig A and VCA-Ig A was detected by ELISA,the level of SA was detected by enzymatic method,and the specificity and sensitivity of the3 test methods were compared.Results The levels of SA,EA-Ig A,VCA-Ig A in nasopharyngeal carcinoma patients were higher than those of the control group,the difference was statistically significant（P〈0.05）; single indicator positive judgment showed diagnostic sensitivity and specificity of SA,VCA-Ig A,EA-Ig A for nasopharyngeal carcinoma were 30.95% and 83.33%,76.19%and 95.24%,57.14% and 92.86%,VCA-Ig A was more sensitive than EA-Ig A; with 2 or more indicators of positive joint detection showed that sensitivity and specificity for the diagnosis of nasopharyngeal the control group were 90.48% and 92.86%.Conclusion Levels of SA,EA-Ig A,and VCA-Ig A increased in patients with nasopharyngeal carcinoma,combined detection of SA,EA-Ig A and VCA-Ig A has important clinical significance for diagnosis and treatment of patients with nasopharyngeal carcinoma,it can screen patients,monitor clinical treatment and assess prognosis.