摘要
目的探讨直肠癌术中应用5-氟尿嘧啶缓释剂的临床疗效以及安全性。方法选取100例直肠癌患者,随机分为观察组与对照组,对比分析两组疗效。结果观察组局部复发、远处转移、生存例数均明显高于对照组(P<0.05),差异具有统计学意义,两组患者在切口感染、盆腔积液、吻合口漏、腹腔脓肿、腹腔出血、肠梗阻等并发症方面比较均无明显差异(P>0.05),差异无统计学意义,两组患者治疗前ALT、AST、CR、BUN、WBC、CD3+、CD4+指标水平无明显差异(P>0.05),差异无统计学意义,治疗后两组患者ALT、AST、CR、BUN、WBC、CD4+指标水平也无明显差异(P>0.05),差异无统计学意义。结论直肠癌术中应用5-氟尿嘧啶缓释剂能够有效提高患者的临床疗效,同时具有较高的安全性,值得在临床中推广应用。
Objective To investigate the the clinical efficacy and safety of 5-fluorouracil sustained release agent in colo- rectal cancer surgery. Methods 100 cases of colorectal cancer patients were randomly divided into the observation group and the control group, comparative analysis of efficacy of the 2 groups were conducted. Results The local recurrence, distant metastasis, and survival number in the observation group were significantly higher than those of the control group( P 〈 0.05 ) , the difference was statistically significant; there had no significant difference in wound infection, pelvic effusion, anastomotic leak,intra-abdomi- nal abscess, abdominal bleeding, intestinal obstruction between the 2 groups ( P 〉 0.05 ) , the difference was not statistically signifi- cant;there had no significant difference in ALT, AST, CR, BUN,WBC, CD3 +, CD4 + index levels before and after treatment be- tween the 2 groups ( P 〉 0.05 ) , the difference was not statistical significant. Conclusion 5-fluorouraeil sustained release agent in colorectal cancer surgery can effectively improve clinical efficacy, and it has high security, it is worthy of clinical application.
出处
《实用癌症杂志》
2015年第11期1675-1677,共3页
The Practical Journal of Cancer
关键词
直肠癌
5-氟尿嘧啶缓释剂
疗效
安全性
Colorectal cancer
5-fluorouracil sustained release agent
Efficacy
Safety