脑清通颗粒对高血压肝热痰瘀证大鼠血浆ET-1和AngⅡ含量的影响

Influence of NaoQingTong Granules on the Contents of Plasma ET-1 and Ang Ⅱ of Rats with Hypertension of Liver-heat Phlegm-stasis Pattern

目的:观察脑清通颗粒对高血压肝热痰瘀证大鼠血浆中内皮素-1(ET-1)和血管紧张素Ⅱ(AngⅡ)含量的影响,探讨其治疗高血压的作用机制。方法:采用慢性复合电刺激加高脂饮食致大鼠高血压肝热痰瘀证模型,测定大鼠血浆中ET-1和AngⅡ的含量。结果:与治疗前及模型组比较,脑清通颗粒各剂量组治疗第2周血压明显降低(P<0.01),第3周降压作用最明显;与模型组比较,脑清通颗粒各剂量组均能降低模型大鼠血浆中ET-1和AngⅡ的含量(P<0.01)。结论:脑清通颗粒可降低高血压肝热痰瘀证模型大鼠血压,其降压机制可能与降低血浆中ET-1和AngⅡ的含量有关。

Objective： To observe the influence of NaoQingTortg granules on the contents of ET- 1 and Ang Ⅱ of rats with hypertension of liver-heat phlegm-stasis pattern, and to explore its mechanism of treating hypertension. Methods： Rat model was prepared by chronic compound electrical stimulation and high fat diet to detect the contents of ET-1 and Ang Ⅱ in the plasma. Results： Compared with before treating and the model group, blood pressure in different doses groups of NaoQingTong granules decreased obviously in the second week after treating （P〈0.01）, the de- crease of blood pressure was the most obvious in the third week; compared with the model group, the contents of ET-1 and Ang Ⅱ in the plasma of rats decreased in different doses groups of NaoQingTong granules （P〈0.01）. Conclusion： NaoQingTong granules could lower blood pressure of the rats with hypertension of liver-heat phlegm-stasis pattern, and its mechanism might be related to decreasing the contents of ET-1 and Ang II in the plasma of rats.