切伦科夫光在生物成像技术中的应用及研究进展

Recent Developments of Cerenkov Luminescence Used in Biological Imaging Technology

切伦科夫光生物成像技术是目前分子影像学中的研究热点,具有成像时间短、探针无毒、成本低、灵敏度高等特点,同时为单一分子探针实现核素和光学显像的双模态成像提供了条件,在肿瘤诊断、监测基因表达、疗效评价和引导肿瘤外科手术等方面展现出巨大的应用潜力。本文详细介绍切伦科夫光生物成像在国际范围内的一些显著进展,对切伦科夫光生物断层成像中重建质量和重建速度优化的研究进行综述;同时针对切伦科夫光生物成像技术因切伦科夫光信号强度弱及组织穿透性差而所受的限制,归纳了国内外学者在成像优化方面所做的努力,讨论了向临床应用转化所需的进一步研究和改进。

Cerenkov luminescence imaging,which provides the advantages of short imaging time,nontoxic probe,low cost,and high sensitivity,is a hot spot in the present molecular imaging research.It makes the possibility for dual-modality of radionuclide and optical imaging achieved by single molecular probes.Cerenkov luminescence imaging has shown enormous potential in cancer diagnosis,monitoring gene expression,assessment of efficacy,guiding cancer surgery and so on.This paper introduces the recent developments of Cerenkov luminescence imaging all over the world.The optimization research of reconstruction quality and speed in Cerenkov luminescence tomography is reviewed.Meanwhile,for the limitations of Cerenkov luminescence imaging due to weak signal and poor penetrating capacity of Cerenkov light,recent developments of Cerenkov luminescence imaging optimization are also described,and the further study and improvement required in clinical translational research are discussed.