期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

老年2型糖尿病患者血清铁蛋白水平与胰岛素抵抗的相关性分析 被引量：2

Association between serum ferritin and insulin resistance in elderly patients with type 2 diabetes mellitus
原文传递
导出
摘要 目的分析老年2型糖尿病患者血清铁蛋白(SF)水平与胰岛素抵抗(IR)的相关性。方法选择40例老年2型糖尿病患者为糖尿病(T2DM)组,40例健康老人为对照组。所有病人均测定体质量指数(BMI)、腹围、血压、血清铁蛋白(SF)、糖化血红蛋白、空腹血糖、血脂、空腹胰岛素等,计算胰岛素抵抗指数(HOMA-IR),比较分析SF与各项指标的相关性。结果糖尿病组血清SF水平明显高于对照组。SF水平与BMI、腹围、血压、空腹血糖、糖化血红蛋白、HOMA-IR成正相关。结论老年T2DM患者SF水平明显升高,SF与糖代谢相关。SF可能是IR的预测指标。 Objective To analyze the association between serum ferritin（ SF） and insulin resistance（ IR） in elderly patients with type 2 diabetes mellitus. Methods Forty elderly patients with type 2 diabetes mellitus were selected as DM group and 40 healthy subjects selected as control group. Body mass index（ BMI）,wasist circumstance（ WC）,systolic blood pressure（ SBP）,diastolic blood pressure（ DBP）,SF,Hb A1 c,fasting plasma glucose（ FPG）,lipids,FINS,HOMA-IR were detected and compared between two groups. Results The level of SF was significantly higher in DM group than that in the control group. The level of SF was significantly positively correlated with BMI,WC,SBP,DBP,FPG,Hb A1 c,HOMAIR. Conclusions The level of SF is significantly higher in elderly patients with type 2 diabetes mellitus,which implicates some association with glucose metabolism and insulin resistance. Ferritin may be a predictor of IR.
作者 庄文翔 倪黎刚
机构地区 江苏省省级机关医院老年科 江苏省省级机关医院检验科
出处 《实用老年医学》 CAS 2015年第10期831-833,共3页 Practical Geriatrics
关键词 老年人 2型糖尿病 血清铁蛋白 胰岛素抵抗 aged type 2 diabetes mellitus serum ferritin insulin resistance
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献10

  • 1Moczulski DK,Grzeszczak W,Gawlik B.Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 daibetic nephropathy[J].Diabetes Care,2001,24(7):1187-1191.
  • 2Alissa EM,Ahmed WH,Al-Ama N,et al.Relationship between indices of iron status and coronary risk factors including diabetes and the metabolic syndrome in Saudi subjects without overt coronary disease[J].J Trace Elem Med Biol,2007,21(3):242-254.
  • 3Forouhi NG,Harding AH,Allison M,et al.Elevated serum ferritin levels predict new-onset type 2 diabetes:results from the EPIC-Norfolk prospective study[J].Diabetologia,2007,50(5):949-956.
  • 4Megan J,Jeanne M,Eliseo G,Serum ferritin and risk of the metabolic syndrome in US,adults[J].Diabetes Care,2004,27(l):2422-2427.
  • 5朱大龙,胡云,韩光晓,顾经宇.2型糖尿病患者正常糖代谢一级亲属胰岛素抵抗及其相关因素分析[J].中国糖尿病杂志,2004,12(1):9-13. 被引量：11
  • 6陈巧芝,赵芳.糖尿病孕妇胰岛素抵抗与胰岛β-细胞分泌功能变化[J].疑难病杂志,2008,7(4):216-217. 被引量：6
  • 7Wilson JG,Lindquist JH,Grambow SC,et al.Potential role of increased iron stores in diabetes[J].Am J Cli Nutri,2005,82(4):1024-1031.
  • 8Jiang R,Manson JE,Meigs JB,et al.Body iron stores in relation to risk of type 2 diabetes in apparently healthy women[J]JAMA,2004,291(6):711-717.
  • 9Claudia B,Ilaria T,Domenico G,et al.Prevalence of body iron excess in the metabolic syndrome[J].Diabetes Care,2005,28(2):2061-2063.
  • 10Van IS,Balkau B,Kettaneh A,et al.Ferritin and transferrin are associated with metabolic syndrome abnormalities and their chang over time in a general population:data from an epidemiological study on the insulin resistance syndrome (DESIR)[J].Diabetes Care,2007,30(7):1795-1801.

二级参考文献21

  • 1弋花妮,李娟,白晶,孙茜,彭婷.妊娠期糖尿病与胰岛素抵抗[J].中国妇幼健康研究,2006,17(3):181-184. 被引量：14
  • 2Martin BC,Warram JH, Krolewski AS, et al. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet, 1992, 17:925-929.
  • 3Groop L, Forsblom L, Lehtovirta M. Characterization of the prediabetic state. Am J Hypertens, 1997, 10 (9 pt 2) : 172s-180s.
  • 4Shaw JT, Levy JC, Turner RC. The relationship between the insulin resistance syndrome and insulin sensitivity in the firstdegree relatives of subjects with non-insulin dependent diabetes mellitus. Diabetes Res Clin Pract,1998,42:91-99.
  • 5Camps I, Biarnes J, Fernandez-Real JM, et al. Insulin resistance and metabolic syndrome in first-degree relatives of patients with NIDDM. Med Clin, 1999,112:281-284.
  • 6Humphriss DB, Stewart MW, Berrish TS, et al. Multiple metabolic abnormalities in normal glucose tolerant relatives of NIDDM families. Diabetologia, 1997,40:1185-1190.
  • 7Costa A, Rios M, Casamitjana R, et al. High prevalence of abnormal glucose tolerance and metabolic disturbances in first degree relatives of NIDDM patients. A study in Catalonia, a mediterranean community. Diabetes Res Clin Pract, 1998,41 : 191-196.
  • 8Amoah AG, Owusu SK, Ayittey OM, et al. Minimal model analyses of beta cell secretion, insulin sensitivity and glucose effectiveness in glucose tolerant, non-diabetic first-degree relatires of Ghanaian patients with type 2 diabetes and healthy control subjects. Ethn Dis, 2001,11:201-210.
  • 9Volk A, Renn W, Overkamp D, et al. Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus. Influence of body weight. Exp Clin Endocrinol Diabetes, 1999,107 : 140-147.
  • 10Jensen CC, Cnop M, Hull RL, et al. Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U. S. Diabetes,2002,51:2170-2178.

共引文献15

同被引文献22

引证文献2

二级引证文献7

实用老年医学
2015年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部