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乌丹降脂胶囊对大鼠非酒精性脂肪肝模型的治疗作用

Study of Danwujiangzhi capsule on treatment in rats with NAFLD
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摘要 目的:探讨乌丹降脂胶囊治疗大鼠非酒精性脂肪肝(NASH)的作用及可能的治疗机制。方法:90只大鼠随机分为6组,分别为正常对照组、模型对照组、易复善组和乌丹降脂胶囊104.17 mg/kg、208.34 mg/kg、416.67 mg/kg剂量组。正常对照组以基础饲料喂食,而模型对照组、易复善组和乌丹降脂胶囊104.17 mg/kg、208.34 mg/kg、416.67 mg/kg剂量组则以高脂饲料喂饲,连续喂养16周;喂养2周后,正常对照组、模型对照组以生理盐水10ml/kg灌胃;易复善组以易复善溶液灌胃85.2mg/kg;乌丹降脂胶囊104.17 mg/kg、208.34 mg/kg、416.67 mg/kg剂量组以乌丹降脂胶囊不同浓度溶液灌胃10ml/kg,连续灌胃14周,测量大鼠体重、肝湿重、肝指数,检测血清生化指标及肝组织病理改变。结果:与模型组相比,乌丹降脂胶囊416.67 mg/kg组及易复善组体重、肝湿重及肝指数均明显降低,血液生化ALT、AST、CHOL、TG、LDL-C、CRP各指标水平明显下降,HDL-C水平明显升高;与模型组相比,病理HE染色结果显示,易复善组与乌丹降脂胶囊416.67 mg/kg组肝脏肝小叶结构恢复,肝细胞索及肝窦结构清晰,肝细胞内脂肪空泡显著减少。结论:乌丹降脂胶囊具有治疗非酒精性脂肪肝作用,机制可能与调节脂质代谢有关。 Objective: To explore the effect and treating mechanism of Danwujiangzhi capsule on experimental model of nonalcoholic fatty liver in rat. Methods: A total of 90 healthy sprague-dawle rats were randomly divided into 6 groups: control group,model control group,Yifusan group and Wudanjiangzhi capsule( 104 mg / kg,208 mg / kg,417 mg / kg) group. Normal control group fed based forage,and the other five groups fed high fat forage,Continuously for 16 weeks. Two weeks later,the normal control group,model control group with saline 10 ml / kg.( d) to fill the stomach,Yifusan group with Yifusan solution for 10 ml/kg.( d) to fill the stomach. Wudanjiangzhi capsule( 104 mg/kg,208 mg / kg,417 mg / kg group with Wudanjiangzhi capsule of different concentration solution 10 ml / kg.( d) to fill the stomach. After 14 weeks,measuring the rat body weight,wet weight of liver and liver index,testing the serum biochemical indicators and liver tissue pathologic change. Results: Compared with model group,the body weight,liver wet weight and liver index of Wudanjiangzhi capsule 416. 67 mg / kg group and Yifusan group is reduced,and the difference was statistically significant( P〈0. 05). Blood biochemical ALT,AST,CHOL,TG,LDL- C,CRP level declined obviously,HDL- C level is increased,and the difference statistically significant( P〈0. 05). Compared with model group,the pathological HE staining results showed that Wudanjiangzhi capsule 417 mg / kg group and Yifusan group liver structure of hepatic lobule,liver cells and hepatic sinus structure clear,liver fat vacuoles in cells was significantly reduced. Conclusion: Wudanjiangzhi capsule has the effect treating nonalcoholic fatty liver disease,the mechanism may be related to the regulation of lipid metabolism.
出处 《中药药理与临床》 CAS CSCD 北大核心 2015年第4期160-162,共3页 Pharmacology and Clinics of Chinese Materia Medica
基金 河北省中医药管理局科学技术研究计划基金项目(编号:2012166) 河北省科技厅科技计划项目(编号:14277753D)
关键词 乌丹降脂胶囊 非酒精性脂肪 Wudanjiangzhi capsule(乌丹降脂胶囊) Yifushan(易复善) nonalcoholic fat
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