Ⅱ型糖尿病患者血清瘦素、脂联素水平分析

Analysis on serum leptin and adiponectin levels in type 2 diabetes mellitus

目的检测Ⅱ型糖尿病患者血清瘦素、脂联素水平,分析其在Ⅱ型糖尿病发生发展中的作用。方法收集2010年1月至2014年6月间收治64例Ⅱ型糖尿病为实验组,40例体检患者为对照组。测定各组空腹血糖、空腹胰岛素、血清瘦素和脂联素水平。结果空腹血糖、空腹血清胰岛素、血清瘦素水平升高,差异有统计学意义(P<0.01);而实验组血清脂联素水平则明显降低,差异有统计学意义(P<0.01)。结论Ⅱ型糖尿病患者可出现高血清瘦素血症和低血清脂联素血症,检测血清瘦素和血清脂联素的水平变化,对Ⅱ型糖尿病的诊治具有一定的临床价值。

Objective To detect serum leptin and adiponectin levels in type 2 diabetes mellitus （T2DM）,and ana-lyzes its effect in T2DM. Methods 64 cases of T2DM between 2010 January and 2014 June were collected as exper-imental group,and 40 cases of physical examination were chosen as control group. Fasting blood glucose,fasting insu-lin,serum leptin and adiponectin levels were measured. Results The levels of fasting blood glucose,fasting insulin and serum leptin levels were increased, while the serum adiponectin levels in experimental group were significantly lower. The differences were statistically significant （P〈0. 01）. Conclusion High serum leptin level and low serum adiponectin level could be appear in patients with T2DM. Detecting their changes has clinical value for diagnosis and treatment of T2DM.