复发性流产患者血清同型半胱氨酸和抗心磷脂抗体水平的检测及临床意义

The detection of serum homocysteine and anticartiolopin antibody in patients with unexplained recurrent spontaneous abortion and its clinical significance

目的通过对原因不明复发性流产(URPL)患者血清同型半胱氨酸(Hcy)、抗心磷脂抗体(ACA)水平的检测,探讨其与URPL的关系,为URPL的预防提供依据。方法对38例URPL患者(URPL组)、42例偶发性流产者(偶发流产组)和42例正常早孕者(正常早孕组)分别采用高效液相色谱分析法、酶联免疫吸附法(ELISA)测空腹血清中Hcy、ACA水平。结果 URPL组患者血清Hcy水平及ACA阳性率均明显高于偶发流产组及正常早孕组(P<0.01或0.05),且两者水平呈正相关(r=0.871,P<0.01);URPL组中ACA阳性患者血清Hcy水平较ACA阴性者高(P<0.01)。结论检测URPL患者的血清Hcy、ACA水平有助于诊断及预后的判断,高Hcy血症及ACA阳性均是URPL发生的重要危险因素。

Objective To explore the relationship between serum homocysteine（Hcy） level and anticardiolipin antibody（ACA） level and unexplained recurrent spontaneous abortion（URPL） through the detection of Hcy and ACA level in patients with URPL, thus to provide evidence for URPL prevention. Methods HPLC analysis and ELISA were utilized to measured fasting serum Hcy and ACA level of URPL Group（38 cases）, Sporadic Abortion Group（42 cases） and Normal Early Pregnancy Group（42 cases）, respectively. Results The serum Hcy level and ACA positive rate of URPL group were significantly higher than those of Sporadic Abortion Group and Normal Pregnancy Group（P〈0.01）, and there was a positive correlation between Hcy level and ACA（r=0.871, P〈0.01）; the serum Hcy level and ACA positive rate of Sporadic Abortion Group were slightly higher than those of Normal Early Pregnant Group, but there was no statistically significance（P〈0.05）; In URPL Group, the serum Hcy level of patients with ACA positive was higher than that of patients with ACA negative（P〈0.01）. Conclusion Detecting serum Hcy and ACA level of patients with URPL contributes to diagnosis and prognosis of URPL. High Hcy hyperlipidemia and ACA positive are important risk factors of the incidence of URPL.