新疆维吾尔族急性缺血性脑卒中短期预后与5-脂氧合酶激活蛋白SG13S32位点及危险因素的相关性研究

Xinjiang Uygur Short- term Prognosis of Acute Cerebral Ischemic Stroke and 5- lipoxygenase- activating Gene SG13S32 Locus Polymorphisms,Risk Factors of the Correlation Research

目的探讨新疆维吾尔族人群急性缺血性脑卒中短期预后与5-脂氧合酶激活蛋白(5-lipoxygenase-activating,ALOX5AP)基因SG13S32位点、年龄、性别、就诊时间等危险因素的相关性。方法选取194例新疆地区急性缺血性脑卒中经相同药物治疗后的维吾尔族患者,应用聚合酶链反应-限制性片段长度多态性技术检测ALOX5AP基因SG13S32位点多态性,采用队列研究的统计分析方法比较不同基因型人群的短期预后改善情况,并经Logistic逐步回归分析,得出预后相关独立因素。结果 5-脂氧合酶激活蛋白基因SG13S32位点不同基因型间维吾尔族急性缺血性脑卒中短期预后改善差异无统计学意义(χ2=0.336,P=0.562)。经Logistic逐步回归分析,年龄、就诊时间及纤维蛋白原为影响维吾尔族急性缺血性脑卒中患者短期预后的独立因素。结论 5-脂氧合酶激活蛋白基因SG13S32位点不同基因型之间急性缺血性脑卒中短期预后改善没有明显差异,且不是影响维吾尔族急性缺血性脑卒中短期预后的独立危险因素。年龄、就诊时间及纤维蛋白原可影响急性缺血性脑卒中短期预后改善。

Objective To investigate the relationship between the short -term prognosis of ischemic stroke in Uygur Xinjiang and SG13S32 locus of 5-lipoxygenase -activating（ALOX5AP） gene,age, gender, visiting time and so on.Methods One hundred and ninety-four Uygur patients who got acute ischemic stroke have the same drug therapy in Xinjiang .The SG13S32 locus ploymorphisms of ALOX5AP gene was determined by using PCR -restriction fragment length polymorphism technique .Cohort study is used to analyze the short-term prognosis of different genotypes .The independent prognostic factors was obtained by the Logistic analysis .Results There were no statistical differences in the short -term prognosis of acute ischemic stroke among different genotypes of ALOX 5AP gene SG13S32 （χ2 =0.336,P=0.562）.The Logistics regression analysis by which we can get that age , visiting time and fibrinogen are independent prognostic factors in acute ischemic stroke in Uygur .Conclusion The short-term prognosis of acute ischemic stroke in Uygur whose in-dependent risk factors is not the ALOX 5AP gene SG13S32 but the age, visiting time and fibrinogen were independent risk factors .