超微粉碎技术对二至丸溶出度的影响

Effects of superfine pulverization technology on the dissolution of Erzhi pill

目的以特女贞苷为溶出指标,对不同粉碎技术制得的二至丸进行溶出度测定,探讨超微粉碎技术对二至丸溶出度的影响。方法用普通粉碎机、超微粉碎机粉碎分别制得药材细粉再制备水蜜丸,采用转篮法和HPLC测定特女贞苷的体外溶出情况,并运用威布尔(Weibull)定律对溶出度进行数据分析。结果二至丸丸A与丸B相比较,两者的特女贞苷溶出参数T50、T60、T70、T80、T90、F1h、F2h均具有显著性差异(P<0.05)。结论采用超微粉碎技术可以提高二至丸的体外溶出度。

Objective To determine the dissolution rate of Erzhi pill which was prepared by using different crushing technologies with specnuezhenide as index,and study the influence of superfine pulverization technology on the dissolution of Erzhi pill. Methods Crude drugs were crushed into the fine powder by employing general crusher and ultra-micro pulverizer,respectively.The water-honeyed pills were prepared by using these fine powders. The method of rotating basket and HPLC were used for the determination of dissolution of specnuezhenide in vitro. The data were analyzed by applying the law of Weibull. Results Compared with Erzhi pill B,the dissolution parameters of specnuezhenide in Erzhi pill A,including T50、T60、T70、T80、T90、F1hand F2 h,showed significant differentce（P〈0.05）. Conclusion Applying the superfine pulverization technology can improve the dissolution of Erzhi pills in vitro.