瑞舒伐他汀与阿托伐他汀对冠心病急性心肌梗死患者血管内皮功能的影响

Effects of rosuvastatin and atorvastatin on vascular endothelial function of patients with acute myocardial infarction in coronary heart disease

目的比较瑞舒伐他汀与阿托伐他汀对冠心病急性心肌梗死患者血管内皮功能的影响。方法选取自2012年10月—2014年10月收治的120例冠心病心肌梗死患者,随机将其分为A、B两组,各60例。患者均接受急性心肌梗死的基础对症处理。A组患者接受瑞舒伐他汀药物方案,B组给予阿托伐他汀方案,坚持治疗6个月,比较不同药物方案对冠心病急性心肌梗死患者血管内皮功能的影响。结果治疗前,2组患者血脂指标、血管内皮指标、血清一氧化氮(NO)、超敏C反应蛋白(hs-CRP)及左心射血分数(LVEF)对比差异无统计学意义(P>0.05);治疗后,A组患者TC、LDL-C值分别为(3.02±0.62)mmol/L、(1.41±0.70)mmol/L,血清NO、hs-CRP分别为(103.32±10.71)μmol、(2.05±0.56)mg/L,与B组相比差异显著(P<0.05);2组患者治疗期间不良反应发生率对比差异无统计学意义(P>0.05)。结论在冠心病急性心肌梗死患者的治疗中,采用瑞舒伐他汀与阿托伐他汀方案,2者在改善患者血管内皮功能、减轻炎症方面均有其疗效,近期疗效相似,且安全性高。但瑞舒伐他汀有更强的减轻炎症反应及降脂功能,值得推广。

Objective To compare the effects of rosuvastatin and atorvastatin on vascular endothelial function of patients with acute myocardial infarction in coronary heart disease. Methods Totally 120 cases of myocardial infarction in pa- tients with coronary heart disease admitted from October 2012 to October 2014 were selected as the research object and were randomly divided into A, B of two groups with 60 cases in each. The patients in two groups received basic symptom- atic treatment of acute myocardial infarction. Group A received rosuvastatin treatment while group B were given atorvastatin treatment. After 6 months of treatment adherence, the effects of different drugs on vascular endothelial function in patients with acute myocardial infarction in coronary heart disease were compared. Results Before the treatment, the contrast differences of blood lipid index, vascular endothelial index, serum NO, hs - CRP and LVEF of two groups were not staffs- tically significant （ P 〉 0. 05 ） ; After the treatment, TC and LDL - C of group A respectively were （ 3.02 ± 0. 62） nmlol/L and （1.41 ±0.70） mmol/L. Serum NO and hs - CRP respectively were （103.32 ± 10. 71）μmol and （2.05±0.56） mg/L. The difference was significant, compared with those of group B （P 〈 0. 05 ） ;The contrast differences of incidence of adverse reactions in two groups were not significant （P 〉 0. 05）. Conclusion In the treatment of patients with acute myo- cardial infarction in coronary heart disease, rosuvastatin and atorvastatin both show their efficacy in improving vascular en- dothelial function and alleviating inflammation. Their recent therapeutic effects arc similar and are of high safety. But rosu- vastatin has a stronger function for inflammatory reactions and lipid lowering, worthy of promotion.