噻托溴铵粉雾剂联合阿奇霉素在支气管扩张中的应用

Observation of tiotropium bromide inhalation combined with azithromycin in treatment of bronchiectasis

目的观察噻托溴铵粉雾剂联合小剂量阿奇霉素长期应用在支气管扩张中的疗效。方法将90例支气管扩张患者随机分为3组,治疗a组:阿奇霉素组,治疗b组:噻托溴铵粉雾剂联合阿奇霉素组,对照组(常规对症治疗)。比较治疗前后患者急性加重次数、肺功能改变、咳痰量变化、CRP变化。结果治疗组各项检测指标均高于对照组,有统计学意义(P<0.05)。治疗b组在改善肺功能方面优于治疗a组(P<0.01)。结论噻托溴铵粉雾剂联合小剂量阿奇霉素能有效改善支气管扩张患者肺功能,减少急性发作次数,减轻临床症状。

Objective To observe the effect of tiotropium bromide inhalation in combination with small dose of azithro- myein long - term in treatment of bronehieetasis. Methods Totally 90 patients with bronchieetasis were randomly divid- ed into three groups,treatment group a：Azithromyein group, treatment group b：tiotropium bromide inhalation tiotropium bromide inhalation, the control group： Conventional treatment group. Comparison before and after treatment in patients with acute exacerbation, changes in lung function, amount of sputum, CRP changes. Results The testing indexes treatment group were higher than control group, with statistical significance（ P 〈 0. 05 ）. Treatment group b in improving lung function better than group a （ P 〈 0.01 ）. Conclusion Tiotropium bromide inhalation in combination with small dose of azithromyein long - term curative can effectively improve lung function in patients with bronchiectasis, decrease the times of acute onset and relieve clinical symptom.