糖尿病前期干预研究进展

The research of prediabetes intervention

糖尿病前期是2型糖尿病发病过程中的必经阶段,也是大血管病变和微血管病变的独立高危因素。参阅国内外相关文献,本文通过对几个大规模糖尿病前期干预研究的分析,概述了近年来中西医干预糖尿病前期的研究成果,并详细论述中药干预糖代谢的有效物质基础及作用机制,大量的临床试验和动物实验证明,许多中药及其提取物具有良好的改善糖代谢的作用,其有效成分主要有生物碱、黄酮等。改善糖代谢的作用机制主要为修复β细胞,增加胰岛素分泌,改善胰岛素抵抗等。

Prediabetes is the necessary stage of type 2 diabetes（T2DM）,and also an independent risk factor of macrovascular and microvascular diseases.Referred to the related literature at home and abroad,we analyzed several large-scale studies of prediabetes intervention.This article summarized the achievements of prediabetes intervention in recent years with western and Chinese medicine.It also showed a detailed discussion on effective ingredients and mechanism of Traditional Chinese medicine in improving glucose metabolism.A large number of clinical trials and animal experiments have proved that lots of Chinese medicines and extracts showed positive effect in improving glucose metabolism.The effective components mainly include alkaloids,flavones and so on.The mechanisms are primarily through repairing beta cells,promoting insulin secretion,improving insulin resistance and so forth.