建立考察抗精神分裂症药物的结构化动物模型

Establishing a structured animal model for screening anti-psychological drugs of schizophrenia

传统的精神分裂症动物模型虽然已得到了广泛应用,但在信度和效度上仍然存在很多问题。我们认为,建立在多重因素整合基础上的多层次化认知障碍动物模型,可以更好地模拟精神分裂症症状,有望成为今后发展精神分裂症动物模型的新方向。为此,我们尝试使用对惊反射前脉冲抑制的多层次性自上而下认知和注意调节的行为范式与多致病因素相结合来建立新一代的精神分裂症的动物模型。新的动物模型对深入了解精神分裂症的致病机制以及寻求更加有效的治疗策略都有重要的意义。

Although some traditional animal models for studying schizophrenia have been wildly used,many problems remain in their credibility and validity.We propose that structured animal models with the integration of multiple symptominducing factors are be better in simulating the symptoms of schizophrenia and represent the new direction of the future animal-model development.In this article,we review previous studies in this line of research and emphasize the importance of combining the behavior paradigm of the structured top-down attentional modulation of prepulse inhibition with multiple pathogenic factors related to schizophrenia to establish a new model generation,which will be of great significance in investigating both the pathogenesis and the treatment of schizophrenia.