非洲马铃薯治疗糖尿病研究进展

Research progress of therapeutic effect of African potato on diabetes

非洲马铃薯(AP)是一种常用的南非治疗糖尿病的传统药物,也具有抗肿瘤、抗感染的作用,是南非新产品药物开发的重要药用植物之一。动物实验研究表明AP具有与剂量正相关的降血糖作用,但其降糖作用机制不明确,这极大地影响的AP的开发应用。文章从AP降血糖研究、降糖机制与安全性3个方面进行综述,对AP抗糖尿病的有效成分和作用机制的研究进展进行分析整理,归纳AP降糖的可能机制主要为3个方面:刺激胰岛素分泌、抗氧化和抗炎。文章提出应用模式动物对AP进行进一步确认药效及其靶点是今后研究的重点,为AP开发研究提供比较系统的信息。

African potato（AP） as one of the important drugs developed newly in South Africa is a commonly used traditional medicine for treating diabetes, and it also be used to resist tumor and infection. Animal experiments shows that AP has an effect of reducing blood sugar, which is positively related to the dosage, but its hypoglycemic mechanism is not clear, which greatly influences the development and utilization of AP. This article summaries from the three aspects of AP as researches of reducing blood glucose effect, possible mechanism of hypoglycemic effect, and safety, analyzes and arranges the research progress on the effective constituents and action mechanism of treating diabetes with AP, and concludes that the potential hypoglycemic mechanism of AP can be divided into three aspects as stimulating the release of insulin, resisting oxidation and resisting inflammatory. It turns out that the research emphasis in the future is to study and confirm the effects and action targets of AP ulteriorly based on the animal models, in order to provide system information for researching the hypoglycemic mechanism of AP deeply.