合并OSAHS的中青年脑梗死患者颈动脉硬化与sICAM-1水平及临床意义

Changes and clinical significance of carotid atherosclerosis and soluble intercellular adhesion molecules-1 in cerebral infarction patients with obstructive sleep apnea-hypopnea syndrome

目的探讨合并睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)的中青年脑梗死(cerebral infarction,CI)患者颈动脉硬化与血清可溶性细胞间黏附分子1(soluble intercellular adhesion molecules-1,s ICAM-1)的关系。方法对68例中青年脑梗死患者进行研究,据是否合并OSAHS分成两组:CI组(35例)及CI合并OSAHS组(33例)。利用彩超检查颈内动脉,观察内中膜厚度(intima-media thickness,IMT)。ELISA法检测s ICAM-1。结果中青年CI合并OSAHS组患者颈内动脉IMT为(1.333±0.185)mm,血清s ICAM-1为(371.727±30.277)ng/m L,两组均高于CI组(P<0.01),且IMT与s ICAM-1呈正相关(r=0.476,P<0.01)。结论合并睡眠呼吸暂停的中青年脑梗死患者颈内动脉内中膜厚度可能与s ICAM-1有关。

Objective To investigate the relationship between carotid atherosclerosis and soluble intercellular adhesion molecules-1 （ sICAM-1 ） in middle-aged and young patients of cerebral infarction （ CI ） with obstructive sleep apnea-hypopnea syndrome（OSAHS）. Methods 68 middle-aged and young patients of CI were divided into two groups according to whether with OSAHS, CI group （ 35 ） and CI with OSAHS group （ 33 ）. All patients were checked carotid artery through color doppler ultrasound and record intima-media thickness （IMT） .The serum sICAM-1 of all patients were assayed by means of double antibody sandwich method and enzyme linked immunosorbent assay （ELISA）. Results The IMT in middle-aged and young patients of CI with OSAHS were （1.333＋0.185）mm, significantly higher than that of CI group （P〈0.01）, the serum levels of sICAM-1 were also significantly higher than that of CI group. IMT were correlated positively with sICAM-I（P〈0.01）. Conclusion The IMT of carotid artery in middle-aged and young patients of CI with OSAHS are probably correlated with sICAM-1.