饮食干预对儿童变态反应性疾病的预防作用和对生长发育的影响

Effects of diet intervention on prevention of eczema and physical growth in high risk infants

目的观察适度水解乳清蛋白配方奶对高变态反应风险儿童发生变态反应性疾病的预防作用,及其对儿童体格生长发育的影响。方法选取2012年10月至2013年10月于德阳市人民医院产科出生及参加儿童保健门诊的具有高变态反应风险的184例儿童为研究对象,采用随机数字表法将其分为干预组(n=91)和非干预组(n=93)。干预组儿童接受纯母乳喂养+适度水解乳清蛋白配方奶的饮食干预,非干预组儿童未接受特殊饮食干预。本研究遵循的程序符合德阳市人民医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书。观察两组儿童变态反应性湿疹的发生情况,比较两组儿童在不同随访时间点的体格生长发育状况。结果两组患儿一般情况比较,差异均无统计学意义(P>0.05)。随访6,12个月时,干预组儿童变态反应性湿疹发生率和严重程度均小于非干预组(P<0.05)。随访3,6,9,12个月时,两组儿童体质量、身长、体质指数(BMI)比较,差异均无统计学意义(P>0.05)。结论采用母乳喂养+适度水解乳清蛋白配方奶的饮食干预能降低高变态反应风险儿童的变态反应性湿疹发生率及其严重程度,对其体格生长发育无影响。

Objective To explore prevention of eczema and physical growth the effects of partially whey in high risk infants. Methods protein hydrolyzed formula on From October 2012 to 2013, a total of 184 high risk infants were included in the study. They were randomly divided into intervention group（n= 91 ） and non-intervention group（n = 93）. Breast feeding＋ partially whey protein hydrolyzed formula were taken in intervention group. Regular formula was taken in non-intervention group. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Peoplers Hospital of Deyang City. Informed consent was obtained from each participants＇s parents. The incidence rate of eczema were observed in both groups, and the physical growth, including the weight, height and body mass index （BMI） ,were evaluated between two groups. Results At 6 months and 12 months follow-up,the incidence rate and the severity of eczema in the intervention group were significantly lower than those of non- intervention group（P〈0. 05）. There were no significant differences on the physical growth between two groups（P〉 0. 05）. Conclusions Partially hydrolyzed whey formula can reduces the incidence rate and severity of eczema in high risk infants. Meanwhile it also can maintain the normal growth of high risk infants.