基质γ-羧基谷氨酸蛋白对冠心病的诊断价值研究

Diagnostic value of matrix gamma carboxy glutamic acid protein for coronary heart disease

目的探讨基质γ-羟基谷氨酸蛋白(MGP)对冠状动脉粥样硬化性心脏病(CHD)的诊断价值。方法采用酶联免疫吸附法检测健康者和不同冠状动脉钙化积分(CACS)CHD患者血清MGP水平,并进行统计分析。以受试者工作特征曲线(ROC曲线)分析MGP对CHD的诊断价值。结果 CHD患者与健康者之间,以及不同CACS水平CHD患者之间血清MGP水平比较差异有统计学意义(P<0.05)。CACS与血清MGP水平呈正相关(P<0.05)。MGP诊断CHD的ROC曲线下面积为0.667,诊断阈值为70.69pg/mL,诊断灵敏度为58.80%,特异度为83.70%,约登指数为0.425。结论 CHD患者血清MGP水平存在明显异常,血清MGP水平与CACS呈正相关。MGP对CHD的诊断价值明显,对疾病的临床预防和早期诊断具有重要作用。

Objective To investigate the diagnostic value of matrix gamma carboxy glutamic acid protein（MGP）for coronary heart disease（CHD）.Methods Enzyme linked immunosorbent assay was performed for the detection of serum MGP level in healthy subjects and CHD patients with different coronary artery calcium score（CACS）.Receiver operating characteristic（ROC）curve was used to analyze the diagnostic value of MGP for CHD.Results Between CHD patients and healthy subjects,and CHD patients with different CACS,the difference of serum MGP level was significant,and serum MGP level was positively correlated with CACS（P〈0.05）.ROC curve of showed that the area under ROC curve was 0.667,the diagnostic threshold was 70.69pg/mL,the diagnostic sensitivity was 58.80%,the specificity was 83.70% and the Youden index was 0.425.Conclusion CHD patients might be with abnormal serum MGP level,which could be positively correlated with CACS.MGP might be with significant value for the diagnosis of CHD,could be useful for the clinical prevention and early diagnosis of CHD.