妊娠期高血压病患者血清多指标检测的临床意义

Clinical significance of serum parameters detection in the diagnosis of hypertension disorders complicating pregnancy

目的探讨血清钙离子(Ca2+)、C反应蛋白(CRP)、尿酸(UA)、同型半胱氨酸(Hcy)及补体C3、C4联合检测对妊娠期高血压病(HDCP)的诊断价值。方法以HDCP确诊患者作为HDCP组,以未合并HDCP的孕妇作为对照组,检测并比较血清Ca2+、CRP、UA、Hcy及补体C3、C4水平,分析各指标单独检测及联合检测对HDCP的诊断性能。结果 HDCP组与对照组血清Ca2+、CRP、UA、Hcy及补体C3、C4水平比较差异有统计学意义(P<0.05)。6项指标联合检测的灵敏度、符合率及正确诊断率高于各指标单独检测(P<0.05),但特异度比较差异无统计学意义(P>0.05)。血清CRP、UA和Hcy水平随着HDCP患者病情进展逐渐升高,而血清Ca2+、补体C3和C4水平逐渐降低,且HDCP患者各亚组间不同指标检测结果比较差异有统计学意义(P<0.05)。结论早期联合检测血清Ca2+、CRP、UA、Hcy及补体C3、C4水平对HDCP的早期诊治和病情评估具有重要意义。

Objective To explore the diagnostic value of combined detection of serum calcium ion（Ca2＋）,C-reaction protein（CRP）,uric acid（UA）,homocysteine（Hcy）and complement C3,C4 in hypertension disorders complicating pregnancy（HDCP）.Methods Patients with HDCP were enrolled as HDCP group,and pregnant women without HDCP were enrolled as control group.Serum parameters,mentioned above,were detected and compared between the two groups.Diagnostic performance of the parameters was also analyzed.Results Serum levels of Ca2＋,CRP,UA,Hcy and complement C3,C4 in HDCP group were significantly different from those in control group（P〈0.05）.Sensitivity,coincidence rate and correct diagnosis rate of combined detection of these six parameters were higher than single detection（P〈0.05）,but the specificity was without significant difference（P〈0.05）.Serum levels of CRP,UA and Hcy increased with the progress of HDCP disease condition,but serum levels of Ca2＋,C3 and C4decreased.Between different sub-group of HDCP patients,serum levels of the six parameters were with significant differences（P〈0.05）.Conclusion Early combined detection of serum Ca2＋,CRP,UA,Hcy and complement C3,C4 could be with significance for the early diagnosis and treatment of HDCP,and also for the condition assessment of HDCP.