免疫固定电泳分型技术在M蛋白相关疾病诊断中的应用

Application of immunofixation electrophoresis typing in the diagnosis of M protein related diseases

目的探讨免疫固定分型技术在M蛋白相关疾病诊断中的应用价值。方法采用免疫球蛋白定量、血清及尿蛋白电泳、血清及尿本周蛋白免疫固定电泳及其他试验,对2例患者标本进行检测和确认。结果结合实验室检测及患者临床体征,1例患者确诊为血清单克隆IgA-κ轻链型多发性骨髓,1例患者确诊为血清IgM-λ型巨球蛋白血症。结论随着电泳技术发展,免疫固定电泳分型技术在M蛋白鉴定中具有较高的特异性和敏感性,应加强其临床应用。

Objective To investigate the diagnostic value of immunofixation electrophoresis typing techniques in M protein related diseases.Methods Specimens of patients were simultaneously tested and identified by quantitative detection of immunoglobulins,immunofixation electrophoresis,and other detections.Results Light chain multiple myeloma of IgA-κmonoclonal type was identified in one patient.Macroglobulinemia of IgM-λtype was identified in the other patient.Conclusion With the development of electrophoresis techniques,immunofixation electrophoresis technique could be with high sensitivity and specificity in identifying M protein,which should be widely applied in clinic.