血浆冷沉淀外用对肛瘘术后创面修复的影响研究

Cryoprecipitate for external use of anal fistula of postoperative wound repair affect clinical research

目的 研究血浆冷沉淀局部外敷对肛瘘手术创面修复的效果.方法 选择低位单纯性肛瘘患者95例,按随机数字表法分为3组,冷沉淀组（32例）术后予冷沉淀敷料（2层）均匀填置于创面,1次/d;康复新组（32例）使用康复新液纱布;湿润烧伤膏（MEBO）组（31例）使用湿润烧伤膏纱布覆盖于创面上.观察三组患者术后不同时间段创面愈合率、愈合所需时间,肉芽增生率、新生上皮覆盖率,以及创面不良反应发生率,并进行统计分析.结果 冷沉淀组术后14、21 d创面愈合率分别为（60.97±4.20）％、（97.69±1.79）％,创面愈合所需时间为（21.31±2.08）d,愈合率高于其他两组、愈合所需时间短于其他两组（P＜0.05）;创面修复平整,术后14、21 d创面肉芽组织增生率[分别为（61.06±13.29）％,（97.63 ±2.81）％]和新生上皮覆盖率[（33.03±4.15）％、（94.97±4.36）％]均高于其他两组（P＜0.05）,创面不良反应较其他两组轻.结论 血浆冷沉淀中所含有的生物活性成分,能促进术后创面组织细胞生长,具有很强的创面修复作用,值得临床推广应用.

Objective To study the cryoprecipitate effect of local external treatment of anal fistula surgical wound repair.Methods A total of 95 cases of low simple anal fistula patients was chosen, and was divided into three groups according to random number table method.The cryoprecipitate group （n =32 cases） began with cryoprecipitate dressing （2 layer） even to fill in a wound, once per day.The Kangfuxin group （n =32 cases） used Kangfuxin solution.The exposed burn ointment （MEBO） group （n =31 cases） used MEBO to cover the wound.The healing time, postoperative wound healing rate, the granulation tissue growth, new epithelial coverage, and adverse reactions were observed.Results The cryoprecipitate group in 14 d and 21 d had postoperative wound healing rate （60.97 ±4.20）% and （97.69 ± 1.79）% ,wound healing time （21.31 ±2.08）days;it had higher healing rate and shorter healing times compared to other two groups （P 〈0.05）.Wound repaired more neatly;and 14d and 21d after the operation, wound granulation tissue growth rate [（61.06 ± 13.29） % and （97.63 ± 2.81） %] and new epithelial coverage [（33.03 ±4.15）% and （94.97 ±4.36）%] were more than the control groups （P 〈0.05） with less adverse reactions relative to control groups.Conclusions The cryoprecipitate contained in the composition has a strong biological activity.It can promote the wound tissue cell growth, and promote the wound repair.