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人乳头瘤病毒16 E6癌蛋白与宫颈癌发生的分子机制的研究进展 被引量：3

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摘要 子宫颈癌是女性生殖系统最常见的恶性肿瘤,严重影响妇女健康[1],随着对其发病机制研究的深入,人乳头瘤病毒（human papilloma virus,HPV）与宫颈癌的关系已越发引起人们关注,HPV早期基因编码产物中,E6蛋白与宫颈癌发生密切相关,能够降解P53蛋白,激活端粒酶,阻碍细胞凋亡的发生,已成为宫颈致癌的研究热点[2].笔者主要阐述了HPV16E6的致癌机制,对其与宫颈癌发病分子机制的研究进展作一综述,为对宫颈癌的防治提供理论依据.
作者 魏朝朝 李乐赛 张弦 陈亦乐
机构地区 南华大学医学院研究生院 中南大学湘雅医学院附属肿瘤医院
出处 《中国医师杂志》 CAS 2015年第10期1596-1597,共2页 Journal of Chinese Physician
基金 基金项目：湖南省科技厅课题资助项目（2013FJ3129）、湖南省自然科学基金联合资助项目（14JJ7090）、湖南省肿瘤医院内青年基金资助项目
关键词 人乳头瘤病毒16/代谢 肿瘤蛋白质类/代谢 宫颈肿瘤/代谢/治疗 综述
分类号 R737.33 [医药卫生—肿瘤]
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参考文献20

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二级参考文献10

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中国医师杂志
2015年 第10期

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