摘要
Novel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O Isopropyl 2′,3′ O isopropylidene uridine 5′ yl N thiophosphoryl threonine and serine methyl esters (5a and 5b) underwent the intramolecular catalyzed hydrolysis reaction.
Novel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O Isopropyl 2′,3′ O isopropylidene uridine 5′ yl N thiophosphoryl threonine and serine methyl esters (5a and 5b) underwent the intramolecular catalyzed hydrolysis reaction.
基金
ProjectsupportedbytheNationalNaturalScienceFoundationofChina (Nos .2 990 2 0 0 3and 39870 4 15 ) ,theMinistryofScienceandTechnology ,theChineseMinistryofEducationandDoctorCandidateInnovationFoundationinTsinghuaUniversity (No .0 92 4 30 30 5 )
