期刊文献+

培美曲塞二钠联合顺铂治疗非小细胞肺癌的临床观察 被引量:2

下载PDF
导出
摘要 目的:对培美曲塞二钠联合顺铂治疗非小细胞肺癌(NSCLC)的疗效进行分析。方法:选择本院于2010年7月-2013年7月收治的NSCLC患者63例分为观察组和对照组。观察组采用培美曲塞二钠联合顺铂进行医治;对照组者采用吉西他滨联合顺铂进行医治。比较其治疗效果和毒副反应发生情况。结果:观察组中17例部分缓解,占45.9%;15例稳定,占40.6%;5例进展,占13.5%;无完全恢复者;总有效率为45.9%;临床增益为86.5%。对照组中10例部分缓解,占38.5%;13例稳定,占50.0%;3例进展,占11.5%;无完全恢复者;总有效率为38.5%;临床增益率为88.5%。两组比较无显著差异,P>0.05。结论:对于晚期NSCLC的医治,培美曲塞二钠联合顺铂是比较理想的治疗选择。
作者 张艳
出处 《医学理论与实践》 2015年第20期2773-2774,共2页 The Journal of Medical Theory and Practice
  • 相关文献

参考文献8

二级参考文献27

  • 1刘联,王秀问,黎莉,张昕,张文东,于学军.含顺铂的三组联合化疗方案治疗晚期非小细胞肺癌的随机对照临床研究[J].癌症,2006,25(8):990-994. 被引量:93
  • 2Kim YH,Kim JS,Choi YH,et al.Phase II stady of docetaxel and cisplatin combination chemotherapy in metastatic or unresectable localized non small cell lung cancer.Int J Clin Oncot,2002,7(2):114-119.
  • 3Jones RJ,Twelves CJ.Pemetrexed:a multitargeted antifolate(ALIMTA),LY-231514).Expert Rev Anticancer Ther,2002,2(1):13-22.
  • 4Rusthoven JJ,Eisenhauer E,Butts C,et al.Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer:A phase II study.National Cancer Institute of Canada Clinical Trials Group.J Clin Oncol,1999,17(4):1994.
  • 5Shepherd FA,Dancry J,Arnold A,et al.Phase II study of pemetrexed disodium,a multitargeted antifolate,and cisplatin as first-line therapy in patients with advanced non-small cell lung carcinoma:A study of the National Cancer Institute of Canada Clinical Trials Group,2001,92(3):595.
  • 6Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011,61 (2):69-90.
  • 7Rollins KD, Lindly C. Pemetrexed: a muhitargetedantifolate[J]. Clin Ther, 2005, 27(9):1343-1382.
  • 8Scagliotti GV, Kortsik C, Dard GG, et al. Pemetrexed combined withoxaliplatin or carboplatin as first-line treatment in advanced- non-small cell lung cancer:amulticenter,phase IItrial[J]. Clin Can- cer Res, 2005, 11:690-696.
  • 9Hanna N, Shepherd FA, Fossela FV, et al. Random lzedphase trial of pemetrexedversus docetaxel in patients with non- small cell lung cancer previously treated with chemotherapy. J Clin Onco, 2004, 22(9):1589-1597.
  • 10Cluleanu TE, Brodowicz T, Belani CP, et al. Maintenance peme- trexedplus best supportive care(BSC)versus placebo plus BSC:A phase IIIstudy[J].JClinOncol, 2008, 26(1):426.

共引文献41

同被引文献10

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部