基于临证医案的单兆伟教授治疗胆汁反流性胃炎药对关联解析

Association Analysis of Pair Medication for Bile Reflux Gastritis Based on Professor SHAN Zhao-wei's Clinical Cases

目的:研究孟河医派传人单兆伟教授治疗胆汁反流性胃炎药对规律。方法:临床采用Medcase V 3.2数据记录挖掘系统对2011—2013年单兆伟教授诊疗医案实时记录,构建单教授医案数据库,以"胆汁反流性胃炎"为核心检索词,进行库内多维度数据检索,将结果导出为二级数据病种专库,用关联解析进行数据挖掘研究。结果:在运算环境中,设置标列参数为[Support=0.40,Confidence=0.87]时,共产生规则项集12条,按照项集内容二次分布,分为6组群,其中支持率在0.50以上的药对:薏苡仁-仙鹤草,薏苡仁-白术,仙鹤草-白术,太子参-白术,太子参-仙鹤草,太子参-薏苡仁。结论:单教授治疗该病常用药对有6组,配伍以健脾益气为主,或健脾化湿兼顾,体现孟河医派顾护中焦脾胃的学术思想。

Objective： To explore the pair medication rules of Professor SHAN Zhao-wei in treating bile reflux gastritis（ BRG）. Method： Medcase V 3. 2 data mining system was used to record all clinical cases that were diagnosed and treated by Prof. SHAN Zhao-wei in 2011-2013 in a real-time manner,and build a database of Professor SHAN＇s clinical cases. The database was searched in multiple dimensions by taking ‘BRG＇as the key word,with the related data retrieved as a secondary disease database; pair medication for BRG was then analyzed according to the secondary database. Result： In the operational environment,if setting the standard for the listed parameters [Support = 0. 40,Confidence = 0. 87],then 12 rule sets of items would be produced totally. According to binomial distribution of item sets content,they were divided into 6 groups. The pair medications whose support rate was more than 0. 50 included Coicis Semen-Agrimoniae Herba,Coicis Semen-Atractylodis Macrocephalae Rhizoma, Agrimoniae Herba-Atractylodis Macrocephalae Rhizoma, Pseudostellariae Radix-Atractylodis Macrocephalae Rhizoma, Pseudostellariae Radix-Agrimonia pilosa, Pseudostellariae Radix-Coicis Semen.Conclusion： Prof. SHAN Zhao-wei commonly uses 6 groups of pair herbals in treating BRG. The treatment methods are mainly to invigorate spleen and supplement qi or invigorate spleen to eliminate dampness,reflecting the academic idea of Menghe Medicine to protect middle burner,spleen and stomach.