热压法生产橡胶膏剂工艺探讨

Discussion on Production Process of Adhesive Plaster with Hot-pressing Method

作者根据20多年的研究和生产实际经验,结合相关文献资料,探讨热压法生产橡胶膏剂在中国的发展过程;热压法生产橡胶膏剂的基质组成及其作用;热压法生产橡胶膏剂的工艺流程和生产操作要点;热压法混炼工序的3种制备方法以及应用现状;热压法涂胶时经常出现的问题和解决方法。引用实例和文献数据说明热压法生产橡胶膏剂的优势,与溶剂法工艺相比,热压法生产橡胶膏剂具有不使用溶媒、成本低、生产安全、环保等优点,厂房占地面积缩小150 m2,薄荷脑等易挥发性药物损失量减少1.7倍,黏性适中、老化慢,生产周期缩短一半,生产效率提高2倍以上。讨论了影响橡胶膏剂产业发展的因素并提出解决方案,认为热压法生产橡胶膏剂具有美好的发展前景,为从事橡胶膏剂研究和生产人员提供一些有应用价值的参考资料。

Combined with relevant literature data,According to his own research and practical production experience of more than 20 years,this article discusses production process of adhesive plaster with hotpressing method and key production operation points,emphasizes on three preparation methods for mixing process of hot-pressing method and problems frequently occurred duringapplication of adhesive and solutions,puts forward factors affecting and solving development of adhesive plaster. Compared with the solvent process, hot-pressing method has advantages of without solvents,low cost,production safety and environmental protection,reducing factory area of 150 m2,menthol and other volatile drug loss reduced by 1. 7 times,viscosity fit,aging slow,shorten period of production cycle half,production efficiency 2 times higher. Adhesive plaster with hot-pressing method has obvious advantages, it is worth popularization and application. This study can provide valuable reference data for people engaged in research and production of adhesive plaster.