维生素E补充对心脑血管疾病影响随机对照试验meta分析

No significant effect of vitamin E supplement on cardio-cerebrovascular diseases: a meta-analysis of randomized controlled trials

目的探讨维生素E补充剂对心脑血管疾病事件（中风、心肌梗死、短暂性脑缺血发作）发生的影响，为心脑血管疾病的防治提供参考依据。方法检索Pubmed、EMBASE、OVID、Healthstar、Cochrane database、Google Scholar、Science CitationIndex等外文数据库和万方数据知识平台、中国知网系列数据库、中国生物医学文献数据库、维普期刊资源整合服务系统等中文数据库，全面收集1980-2014年间维生素E补充与心脑血管疾病事件发生关系的随机对照试验文献，采用Revman5．1软件对纳入的文献进行Meta分析。结果最终纳入13篇英文文献，累计维生素E组干预人数62871例，安慰剂组对照人数62837例；Meta分析结果显示，维生素E补充对心脑血管疾病事件的发生无显著影响（RR=n99，95％CI=0．96—1．02），对中风的发生无显著影响（RR=1．03，95％CI=0.96—1．10），肄0肌梗死的发生无显著影响（RR=Q99，95％CI=Q93—1．04），对短暂性脑缺血发作无显著影响（RR=Q94，95％CI=Q82～1．09）；亚组分析结果显示，性别、随访时间、是否有其他干预措施和维生素E的剂量均对心脑血管疾病事件的发生无显著影响（均P〉0．05）。结论补充维生素E对心脑血管疾病事件的发生无显著影响。

Objective To investigate the effect of vitamin E supplementation on cardio-cerebrovascular disease events （ stroke, myocardial infarction, and transient ischemic attack） and to provide a reference for the prevention and treatment of cardio-cerebrovascular diseases. Methods The published literature from 1980 through 2014 on randomized controlled trials（RCTs） on the relationship between vitamin E supplement and cardio-cerebrovascular diseases were searched through Pubmed, EMBASE, OVID, Healthstar, Cochrane database, Google Scholar, Science Citation Index, Wanfang data- base, China National Knowledge Infrastructure, Chinese Biomedical Data-Base, and VIP Chinese Science and Technology Periodical Database. The data were analyzed with meta-analysis using Revman software version 5.1. Results Totally 13 RCTs were involved in the analysis, including 62 871 vitamin E intervention cases and 62 837 placebo controls. The meta analysis showed that vitamin E supplementation had no effect on the incidence of cardiovascular disease events （relative risk （RR） = 0. 99,95 % confidence interval（95 % CI） = 0.96 - 1.02 ）, stroke （ RR = 1.03,95 % CI = 0. 96 - 1.10 ）, myo- cardial infarction （RR =0. 99,95% CI = 0. 93 - 1.04）, and transient ischemic attacks （ RR = 0. 94,95% CI = 0. 82 - 1.09）. Sub- group analysis indicated that gender,follow-up duration,whether with other interventions,and doses of vitamin E had no con- founding effect on the occurrence of cardio-cerebrovascular disease in the RCTs （ all P 〉 0. 05 ）. Conclusion Vitamin E might have no significant influence on cardio-cerebrovascular disease events.