基质金属蛋白酶9在膀胱癌组织中表达及临床意义的Meta分析

目的研究基质金属蛋白酶9（MMP-9）在膀胱癌中的表达及临床意义。方法对1998~2014年间国内中文期刊（说明对象来源）发表的相关文献进行Meta分析,以膀胱癌组织为病例组,以正常膀胱黏膜组织为对照组;以比值比（OR）为效应指标。然后应用Rev Man 5.2软件对数据进行统计处理,计算合并OR值及95%置信区间,同时绘制Meta分析森林图。结果 12篇文献纳入选中,总样本量约792例进行Meta分析。膀胱癌组织组与正常膀胱组织组、浅表性膀胱癌组与浸润性膀胱癌组、低级别膀胱癌组与高级别膀胱癌组的OR值分别为58.99、0.17、0.29。MMP-9的阳性率在膀胱癌组明显高于正常膀胱组织组,在浸润性膀胱癌组明显高于浅表性膀胱癌组,在高级别膀胱癌组明显高于低级别膀胱癌组。结论 MMP-9的高表达在膀胱癌发生、发展中有一定的作用,检测MMP-9的表达有助于了解膀胱癌的生物学特性,为指导临床治疗及估计预后提供信息。

Objective To study the expression of matrix metalloproteinases 9 （MMP-9） in bladder cancer and its clinical significance. Methods Meta analysis of relative literatures published In domestic Chinese journals from 1998 to 2014 ,bladder cancer tissues as cases, normal bladder mucous membrane tissues as control group; Odds ratio （OR） as the effect index. Then apply RevMan 5.2 software to statistical data, calculate merger OR values and 95% confidence interval, and draw the forest map o1＂ Meta analysis. Results 12 studies involving 792 patients that met the inclusion criteria, were included in the Meta analysis. OR values in bladder cancer tissue and normal bladder tissue group, superficial bladder cancer group and invasive bladder cancer group, low grade bladder cancer group and senior grade bladder cancer group were 58.99,0.17,0.29. The positive rate of MMP-9 in bladder cancer group were significantly higher than that in normal bladder tissue group, in invasive bladder cancer group were significantly higher than that of superficial bladder cancer group, in senior grade bladder cancer group were significantly higher than the low grade bladder cancer group. Conclusion The high expression of MMP-9 have a role in in bladder cancer occurrence and development; to detect the expression of MMP-9 contributes to the understanding of the biology of bladder cancer, and provide information for clinical treatment and prognosis.