甲状腺自身抗体与复发性流产关系的研究进展

Advance of the Relevance between Thyroid Autoantibodies and Recurrent Spontaneous Abortion

甲状腺自身抗体(AT-Ab)是自身免疫因素中一个相对独立以及重要的自身抗体,其阳性是自身免疫功能紊乱的重要标志之一。AT-Ab对妊娠妇女可产生诸多不良影响,导致不良妊娠结局的发生,其中包括复发性流产(RSA)。其发病机制目前尚未明确,但两者的相关性得到了越来越多的研究,给予静脉注射免疫球蛋白、左旋甲状腺素片、激素或肝素与阿司匹林联合以及中医中药等治疗可减少RSA的发生,提高妊娠率。因此,加强对AT-Ab的认识,将有助于降低不良妊娠结局的风险,对临床治疗提供一定的帮助。

Thyroid autoantibodies are the relatively independent and important markers of autoimmune dysfunction. The presence of positive thyroid autoantibodies in pregnancy is associated with some adverse effects on fetal maternal outcomes, including recurrent spontaneous abortion. The pathogenesis is still unclear. Recently, more and more studies on the correlation between them have been done. Giving intravenous immunoglobulin,levothyroxine,hormone or heparin and aspirin combination and Chinese medicine can not only decrease the recurrent abortion, but also improve the pregnancy rate. Therefore, strengthening the under- standing of thyroid autoantibodies will help to reduce the risk of adverse pregnancy outcomes and provide some help for the clinical treatment.