摘要
生长抑制因子(ING)家族是候选的抑癌基因,ING4基因是该家族的新成员。ING4基因在正常组织中表达丰富,在胃癌、结直肠癌、肝细胞癌、胰腺癌、肺癌、乳腺癌、卵巢癌、前列腺癌、膀胱癌、神经胶质瘤、黑色素瘤等多种恶性肿瘤组织中表达明显下调。ING4基因不仅参与了肿瘤的发生、发展及预后,还能增强肿瘤细胞对化疗药物的敏感性。
Inhibitor of growth （ING） family is considered to be a candidate tumor suppressor gene, and ING4 gene is a new member of the family. ING4 was significantly downregnlated in several tumors ： gastric cancer, colorectal cancer, hepatocellular carcinoma, pancreatic cancer, lung cancer, breast cancer, ovarian caneer, prostate cancer, bladder cancer, glioma, and melanoma. ING4 is not only involved in the development and prognosis of tumors, but also enhances the sensitivity of tumor cells to chemotherapeutic drugs.
出处
《医学综述》
2015年第21期3910-3913,共4页
Medical Recapitulate
