IVF-ET拮抗剂方案中促性腺激素释放激素激动剂扳机后的黄体支持

Luteal phase support after GnRH agonist trigger in IVF-ET cycles

促性腺激素释放激素激动剂(GnRH-a)作为体外受精-胚胎移植(IVF-ET)周期中促卵泡成熟的药物,能够明显减少卵巢过度刺激综合征(OHSS)的发生率。GnRH-a扳机后使用传统的雌、孕激素作为黄体支持方法会导致妊娠结局较差,但如果采用改良的黄体支持方案,则妊娠结局与传统人绒毛膜促性腺激素(HCG)扳机相似,同时又降低了OHSS的发生率。本文将对GnRH-a扳机后的黄体功能及其支持方案进行综述。

The major advantage of triggering final oocyte maturation with a single bolus of GnRH agonist（GnRH-a）in IVF-ET cycles is the reduction in the occurrence of ovarian hyperstimulation syndrome （OHSS）. Traditional luteal phase support in the form of progesterone and estradiol after GnRH-a trigger would lead to poor pregnancy outcome. Several recent studies reported that GnRH-a trigger combined with a modified luteal support regimen could achieve a reproductive outcome comparable to that after HCG triggering. This paper reviews the current status of the different approaches available for the luteal support after GnRH-a trigger.