中心动脉压及脉压对冠状动脉病变的影响

Influence of central aortic and pulse pressure in coronary Artery Disease

目的:评价有创中心动脉压及脉压对冠状动脉病变的影响。方法:选取173例疑诊断为冠心病的患者,并根据冠状动脉造影分为非冠心病组(狭窄<50%)、冠心病组(≥50%),冠心病组分为单支病变组、双支病变组、三支病变组。结果:非冠心病组与冠心病组比较,中心动脉收缩压(SBP-C)、中心动脉舒张压(DBP-C)、中心动脉脉压(PP-C)均具有统计学意义(P<0.05)。在单支、双支、三支冠脉病变各组间比较,SBP-C、PP-C具有统计学意义(P<0.05)。Logistic回归显示,SBP-C[P=0.019,OR=1.207,95%CI(1.032,1.412)]及PP-C[P=0.023,OR=1.166,95%CI(1.021,1.332)]与冠状动脉多支病变具有相关性。结论 :冠心病患者中SBP-C、PP-C明显增高,而DBP-C明显低于非冠心病患者。SBP-C、PP-C越高,冠状动脉病变越严重。SBP-C、PP-C是冠状动脉多支病变的独立危险因素。

Objective To investigate the influence of central aortic pressure and pulse pressure in coronary Artery. Methods The research involed 173 patients who were suspected coronary heart disease （CHD） in the Fifth People′s Hospital of Chengdu city. The patients were divided into non-coronary disease and coronary disease groups. Patients were divided into one- vessel, two- vessels and three-vessels in coronary disease groups. The data were analyzed by using spass 17.0 software. Results SBP-C,DBP-C and PP-C had statistical significance compared with non-coronary disease （P 〈 0.05）.SBP-C and PP-C had significant difference between single-branch and multiple-branch group（P 〈 0.05）.Logistic multivariate analysis indicated that SBP-C [P = 0.019,OR = 1.207, 95%CI（1.032,1.412）]and PP-C [P = 0.023, OR = 1.166,95%CI （1.021,1.332）] had significant correlation. Conclusion Compared with non-coronary, SBP-C and PP-C were higher, while DBP-C was lower. The higher SBP-C and PP-C are,the worse coronary artery is. SBP-C and PP-C are predispose risk factors for multiple-vessels coronary disease.