正常新生儿脑发育的1H-MRS研究

Proton Magnetic Resonance Spectroscopy Study of Normal Neonatal Brain Development

目的:通过运用单体素氢质子波谱技术(1H-MRS)观察健康新生儿脑组织右基底节和右额叶各代谢物比值随胎龄的变化规律,提高对新生儿脑发育的认识。方法:本研究纳入69例新生儿,包括25例早产儿和44例足月儿。运用点分辨波谱序列对其脑组织各兴趣区所得代谢数据进行分析研究。结果:NAA/Cr、NAA/Cho与胎龄呈正相关(右基底节r=0.27、0.63,右额叶r=0.44、0.64,均P<0.05);Cho/Cr与胎龄呈负相关(右基底节r=-0.51,右额叶r=-0.41,均P<0.05)。同胎龄组各变量存在直线回归关系。右基底节NAA/Cho高于右额叶(P<0.05)。结论:新生儿脑组织代谢物水平与胎龄相关,MRS可定量检测新生儿脑成熟度。

Objective Single voxel proton spectroscopy technique （1H-MRS）was performed in the healthy newborn brain tissue to investigate the metabolic ratio in the right basal ganglia and the right frontal lobe changes with gestational age, and to improve the understanding of the neonatal brain development. Methods In this study, 69 newborns were selected, including twenty-five premature and forty-four term neonates. By using the Gesell developmental scale to evaluate brain development , they all had normal neurologic outcomes at 12-months corrected age. A point-resolved spectroscopy sequence was used to study the metabolic data obtained from each region of interest. Results N-acetylaspartate： creatine and N-acetylaspartate：choline were positively correlated with gestational age （the right basal ganglia r = 0.27, 0.63, the right frontal lobe r = 0.44, 0.64 respectively, P 〈 0.05） and choline：creatine was negative （the right basal ganglia r = -0.51,the right frontal lobe r = -0.41, P 〈 0.05）, with a linear regression relationship among variables. In the same gestational age group , the N-acetylaspartate： choline of the right basal ganglia was higher than that of the right frontal lobe , and the metabolic ratios among the anatomic locations were significantly different （P 〈 0.05）. Conclusion Neonatal brain metabolite levels are associated with gestational age , and MRS can monitor newborn brain maturation quantitatively.