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女性肿瘤患者生育力的保存 被引量:4

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摘要 大剂量放、化疗及骨髓移植(bone marrow transplantation, BMT )可使超过90%年轻女性恶性肿瘤患者病情得到缓解[1]。而放化疗作用机制主要是抑制细胞增殖和干扰DNA结构与功能,具有细胞毒性,卵巢组织对其非常敏感[2],同时性腺功能亦容易受到放化疗损害,进而导致女性生育力下降,美国临床肿瘤学会(ASCO)研究指出了放、化疗导致永久性闭经的危险性[3]。因此,在接受放化疗之前,能否找到一种合理方法保存患者生育能力,具有十分重要的临床意义。
作者 韩莹 张云山
机构地区 天津医科大学
出处 《实用医学杂志》 CAS 北大核心 2015年第20期3454-3456,共3页 The Journal of Practical Medicine
基金 天津市卫生局资助项目(编号:12ZK101)
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同被引文献58

  • 1温忠麟,侯杰泰,张雷.调节效应与中介效应的比较和应用[J].心理学报,2005,37(2):268-274. 被引量:3137
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  • 3Huang JY,TulandiT,Holzer H,ei al.Cryopreservation of o- varian tissue and in vitro matured oocytes in a female with mosa- ic Turner syndrome:CaseReport[J].HumReprod,2008,23(2):336-339.
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  • 7te Velde ER,Pearson PL.The variability of female reproductive ageing[J].Hum ReprodUpdate,2002,8(2):141-154.
  • 8American Cancer Society,Cancer facts and figures-006[J].A- merican Cancer Society:Atlanta,GA.2006,15(5):860-764.
  • 9Donnez J,Dolmans MM,Pellicer A,et al.Restoration of ovari- an activity and pregnancy after transplantation of cryopreserved ovarian tissue:a review of 60 cases of reimplantation[J].Fertil Steril,2013,99(6):1503-1513.
  • 10Jeong-Yeol Park,Hextan Yuen Sheung Ngan,Won Park,etal,Asian Society of Gynecologic Oncology International Workshop 2014 J Gynecol Oncol,2015,26(1):68-74.

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