某县级二甲综合医院399例药品不良反应报告分析

Analysis of 399 Cases of ADR in County-level Second Grade Class A Hospital

目的：了解某县级二级甲等综合医院药品不良反应（ADR）发生的一般规律及特点,为临床合理用药提供参考。方法：回顾性分析某县级二级甲等综合医院2011-2014年上报至国家ADR监测网的ADR报告399例。结果：399例ADR中,0~10岁的儿童较多,占39.35%;以静脉给药方式为主,占91.98%;引发ADR的药品最多的是抗菌药物（占56.39%）,其中头孢菌素类所占比例最高（占19.55%）;ADR临床表现以皮肤及其附件损害最为常见（占50.38%）。结论：掌握ADR监测和报告现状,从中提取有价值的警戒信号,有助于保障患者用药安全。

OBJECTIVE： To explore the regularity and the characteristics of ADR in county-level second grade class A hospi- tal, in order to promote rational drug use in the clinic. METHODS： In retrospective study, 399 ADR reported to National ADR Monitoring Network by county-level second grade class A hospital from 2011 to 2014 were analyzed. RESULTS： 399 cases of ADR most happened in 0-10 year-old children （39.35%） ; most of ADR cases （91.98%） were related to intravenous administra- tion; 56.39% of ADR cases were caused by antibiotics （56.39%）, among which cephalosporin antibiotics took up the highest pro- portion （19.55 % ）. ADR mainly manifested as lesion of skin and appendants （50.38%）. CONCLUSIONS： It contributes to guaran- tee the safety of drug use that mastering the situation of ADR monitoring and report and extracting valuable warning sign.