血必净注射液治疗重症颅脑外伤患者的回顾性分析

Efficacy Observation of Xuebijing Injection in the Treatment of Severe Craniocerebral Trauma

目的:评价血必净注射液在重症颅脑外伤治疗中的疗效。方法:回顾性收集我院神经外科收治的重症颅脑外伤患者67例,按治疗方法分为治疗组(33例)和对照组(34例),两组患者给予吸氧、脱水、营养脑神经、抗感染等常规治疗,治疗组患者在此基础上给予血必净注射液50 ml/次,tid,ivgtt。观察两组患者治疗后凝血酶原时间(PT)、凝血酶时间(TT)、血小板计数(PLT)、纤维蛋白原(FIB)、肌酸激酶(CK)、乳酸(LA)、D-二聚体(D-D)、血气指标[二氧化碳分压(PaCO2)、氧分压(PaO2)、碳酸氢根(HCO3-)]及治疗6个月的预后情况,并评价疗效。结果:治疗后,两组患者PT、TT、PLT、FIB、CK、LA、D-D、PaCO2、PaO2、HCO3-测定值均优于治疗前,且治疗组优于对照组,差异均有统计学意义(P<0.05);治疗组患者治疗6个月后的预后良好率(78.79%)显著优于对照组(55.88%),差异有统计学意义(P<0.05)。结论:血必净注射液治疗重症颅脑外伤患者可以改善患者的凝血功能、血气水平、炎症反应,有利于改善患者的预后。

OBJECTIVE： To evaluate therapeutic efficacy of Xuebijing injection in the treatment of severe craniocerebral trau- ma. METHODS： 67 patients with severe craniocerebral trauma selected from neurosurgery department of our hospital were Treat- ment method divided into treatment group （33 cases） and control group （34 cases）. Observation group was given conventional treat- ment, i.g. oxygen inhalation, dehydration, nourish cranial nerve, anti-infection. Treatment group On the basis of the control group was given Xuebijing injection 50 ml/time, rid, ivgtt. PT, TT, PLT, FIB, CK, LA, D-D, blood gas index （PaCO2, PaO2, HCO3-） of 2 groups were observed after 7 days of treatment, and prognosis of 2 groups were evaluated after 6 months as well as therapettin efficacy. RESULTS： After treatment, PT, TT, PLT, FIB, CK, LA, D-D, PaCO2, PaO2 and HCO3- of 2 groups were all better than before, and the treatment group was better than the control group, with statistical significance （P〈0.05）. The rate of good prognosis in treatment group （78.79%） was significantly better than in control group （55.88%） after 6 months of treat- ment, with statistical significance （P〈0.05）. CONCLUSIONS： Xuebijing injection in the treatment of severe craniocerebral trau- ma can improve coagulation function, blood gas levels and the inflammatory reaction, and is conducive to improve the patient＇s prognosis.