摘要
目的:观察疏血通联合丁苯酞治疗老年急性大面积脑梗死的疗效及安全性。方法:选取老年急性大面积脑梗死患者76例,按随机数字表法分为观察组和对照组,各38例。对照组患者采用丁苯酞100 ml,bid;观察组患者在对照组基础上加用疏血通注射液6 ml加入5%葡萄糖注射液200 ml,ivgtt,qd。观察两组患者治疗前后神经功能缺损程度评分、凝血指标、红细胞比积、血小板聚集率变化及临床疗效。结果:治疗后14 d,观察组患者的功能缺损评分[(3.57±0.25)分]明显低于对照组[(5.98±1.13)分],差异有统计学意义(P<0.05);治疗后,观察组患者总有效率(81.58%)显著高于对照组(57.89%),差异有统计学意义(P<0.05);观察组患者血小板聚集率[(52.38±3.74)%]、红细胞比积[(36.21±3.26)%]均显著低于对照组,差异有统计学意义(P<0.05)。治疗前后,两组患者的凝血指标均无明显变化,差异无统计学意义(P>0.05);两组患者均未见明显不良发应发生。结论:疏血通联合丁苯酞治疗老年急性大面积脑梗死疗效较好,对患者神经功能恢复有着积极的影响,且安全性高。
OBJECTIVE: To observe therapeutic efficacy and safety of shuxuetong combined with butylphthalide in the treat- ment of elderly acute massive cerebral infarction. METHODS: 76 elderly patients with acute massive cerebral infarction selected were randomly divided into observation group and control group, with 38 cases in each group. Control group was treated with bu- tylphthalide, 100 ml, bid; observation group was additionally given shuxuetong 6 ml added into 55 Glucose injection 200 ml, ivgtt, qd, on the basis of control group. The NIHSS, coagulation index, hematocrit, platelet aggregation rate and clinical efficacy were observed in 2 groups before and after treatment. RESULTS: After 14 d treatment, NIHSS of observation group [(3.57 + 0.25) points] was significantly lower than that of control group [(5.98 ±1.13) points], with statistical significance (P〈0.05); after treat- ment, total effective rate of observation group (81.58%) was significantly higher than that of control group (57.89%), with statis- tical significance (P〈0.05) ; platelet aggregation rate [(52.38 ± 3.74)%] and hematocrit [(36.21± 3.26)%] of observation group were significantly lower than those of control group, with statistical significance (P〈0.05). Before and after treatment, coagula- tion indexes of both groups had no significant change, without statistical significance (P〉0.05). No obvious ADR was found in 2 groups. CONCLUSIONS : Shuxuetong combined with butylphthalide is effective in the treatment of elderly acute massive cerebral infarction, and help restore neurological function with good safety.
出处
《中国药房》
CAS
北大核心
2015年第32期4577-4579,共3页
China Pharmacy
关键词
疏血通
丁苯酞
急性大面积脑梗死
Shuxuetong
Butylphthalide
Acute massive cerebral infarction