局部使用血管收缩药术中止血对血流动力学的影响及危害

The influence and harm of hemodynamics while local use vasoconstrictor in intraoperative hemostasis

背景血管收缩药是药物止血方法中重要的组成部分，局部用药后通过收缩出血部位血管壁达到止血目的，但局部吸收血管收缩药后对全身血流动力学会产生一定影响，甚至导致不良事件发生。目的提高对局部使用血管收缩药用于术中止血对血流动力学的影响及危害的认识，避免恶性事件发生。内容介绍目前临床常用于术中止血的血管收缩药的特点、常用方法、对全身血流动力学的影响及危害、临床应用现状及展望。趋向局部使用血管收缩药用于术中止血并未因止血技术的发展而淘汰，进一步认识血管收缩药术中局部使用过程中对血流动力学的影响及危害，提高临床工作安全性。

Background Intraoperative hemostasis is an important procedure of surgical operation. Vasoconstrictor is one kind of hemostatie drugs used in clinic, which stops bleeding by contracting the injured blood vessel wall. However, locally administered vasoconstrictor can involve changes in systemic hemodynamics, even lead to the occurrence of adverse events after absorbed into circulation. Objective To strengthen the understanding of the adverse hemodynamic effects and the consequent hazards of local using of vasoconstrictor for intraoperative hemostatic. Content This review summarized the characteristics, systemic hemosynamic and the possible consequent adverse events of vasoconstrictors commonly used during intraoperative hemostasis, and introduced the administering methods and the clinical application. Trend Searching the ideal vasoconstrictor and rational application methods fit for both reducing intraoperative hemorrhage and minimizing the influence on hemodynamies.