鼻内激素联合孟鲁司特治疗儿童OSAHS的临床观察

Clinical efficacy of combined treatment with Intranasal steroids and montelukast for OSAHS in children

目的观察鼻内激素联合孟鲁司特治疗儿童阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hypopnea syndrom，OSAHS）的短期疗效。方法入选的51例OSAHS患儿作为研究对象，随机分成2组。联合用药组（n=26）采用鼻内激素与孟鲁司特联合治疗，对照组（n=25）单用鼻内激素治疗。均连续治疗12周。治疗前后进行电子鼻咽镜检查，统计患者治疗前后睡眠呼吸暂停低通气指数（AHI）和最低血氧饱和度（Lsao2），比较2组的差异。结果治疗前与治疗后电子鼻咽镜检查腺样体缩小程度组间比较差异无统计学意义（P〉0．05），而治疗后2组睡眠呼吸监测的主要指标AHI及Lsao2的差异有统计学意义（P〈0．05）。结论鼻内激素联合孟鲁司特治疗儿童OSAHS的短期疗效优于单纯使用鼻内激素。

Objective To observe the short - term efficacy of combined treatment with intranasal steroids and montelukast for Obstructive Sleep Apnea Hypopnea Syndrome in children. Methods 51 cases of children with OSAHS were selected, and randomly divide drug combinatioil group （ n = 26 ） treated with intranasal steroids combined with montelukast for 12 weeks and control group （n = 25 ） treated with intranasal steroids only for 12 weeks. Electronic nasopharyngoscope examination were performed before and after treatment and compare the difference between two groups, and compare the difference between the main indicators of sleep respiratory monitoring in the two groups： sleep apnea hypopnea index （AHI） and the lowest oxygen saturation （Lsao2 ）. Results There is no statistically significant difference between the two groups after the treatment of electronic nasopharyngoscopy adenoids shrink degree （ P 〉 0.05 ） , while a statistical- ly significant difference exists between the two groups： AHI and Lsao2 after the treatment of sleep respiration monitoring index （ P 〈 0.05 ）. Conclusion The short - term effect of combined treatment with intranasal eorticosteroids and montelukast is better than that of treatment with intranasal steroids only in the children with OSAHS.