不同疗程左氧氟沙星辅助治疗结核性胸膜炎效果分析

Effect of different course of levofloxacin in the treatment of tuberculous pleuritis

目的：探讨不同疗程左氧氟沙星辅助治疗结核性胸膜炎的临床效果及安全性。方法选取本院84例结核性胸膜炎患者为研究对象，按照疗程不同分为对照组与治疗组，每组各42例。两组患者均采用四联抗结核标准治疗，对照组患者加用左氧氟沙星治疗1周，治疗组患者加用左氧氟沙星治疗2周-3个月。比较两组患者临床疗效、胸腔穿刺抽液量及不良反应发生情况。结果两组患者胸腔穿刺抽液量及治疗有效率比较均无显著差异（P＞0.05）；治疗组患者不良反应发生率明显高于对照组（P＜0.05）。结论结核性胸膜炎患者于四联抗结核标准治疗基础上加用长疗程左氧氟沙星治疗，与加用短疗程疗效相当，但前者增加不良反应发生率。

ObjectiveTo explore the clinical curative effect and safety of different courses of levolfoxacin in the treatment of tuberculous pleuritis.MethodSelected 84 cases of patients with tuberculous pleuritis in our hospital as research objects, according to the treatment regimen, they were divided into control group and treatment group, 42 cases in each group. All patients were treated with anti-tuberculosis standard therapy;control group patients were treated with levolfoxacin for one week; treatment group patients were treated with levolfoxacin for 2 weeks to 3 months. Clinical efifcacy, pleural lfuid volume, adverse reactions were compared between the two groups.ResultThere were no signiifcant differences in clinical efifcacy and pleural lfuid volume between the two groups （P〉0.05）; adverse reaction rate of treatment group was higher than control group （P〈0.05）.ConclusionPatients with tuberculous pleuritis adding the treatment of long course of levolfoxacin have a matching curative effect with short course of levolfoxacin therapy on the basis of quadruple anti-TB’ treatment standard, but the former has more adverse reactions.