功能磁共振用于肿瘤光热和光动力协同治疗的实时监测研究

Real-time monitoring of tumor response to photothermal/photodynamic therapy by functional magnetic resonance imaging

将实验动物分为光热治疗组、光动力治疗组、光热和光动力协同治疗组,使用T2加权和扩散加权两种磁共振成像方式对治疗效果进行实时监测,并使用病理学方法对磁共振检测效果进行验证.实验结果发现,两个单纯治疗组中肿瘤并未被完全杀灭;而协同治疗组中,肿瘤被完全杀灭.磁共振作为无创监测手段,在疗效评价中有巨大的应用价值,并可对纳米粒子的设计合成起到指导作用.

This paper assess the long -term curative effect of tumor after different treatment strategies . Compared with photodynamic therapy or photothermal therapy alone , the combined therapy showed a significantly synergistic effect , which was demonstrated by functional MRI .The results provide a di-rect, non-invasive method for in vivo monitoring of the treatment response to nanoparticle -mediated PTT, which can be used to guide cancer therapy to improve potential clinical outcomes .