摘要
目的探讨妊娠期糖尿病(GDM)患者脂蛋白相关磷脂酶A2(Lp-PLA2)的活性变化及其与妊娠不良结局的关系。方法以该院产科门诊2012年9月-2014年1月收集的62例GDM孕妇作为研究对象,其中血糖控制良好的孕妇35例(A组)、血糖未良好控制孕妇27例(B组)。另选取同期正常妊娠妇女30例作为对照组。检测并比较3组研究对象Lp-PLA2活性及妊娠结局差异。结果 3组研究对象Lp-PLA2、空腹血糖值(FBG)、2 h餐后血糖值(2h BG)、胰岛素抵抗指数(HOMAIR)、甘油三酯(TG)值比较,差异均有统计学意义(P<0.05)。B组患者的Lp-PLA2、FBG、2h BG、HOMA-IR、TG值均显著高于A组及对照组(P<0.05);A组Lp-PLA2、FBG、2h BG、HOMA-IR值均显著高于对照组(P<0.05)。B组巨大儿发生率(33.33%)、胎膜早破率(22.22%)、早产率(37.04%)均显著高于A组和对照组(P<0.05)。GDM孕妇的FBG值与LpPLA2呈正相关(P<0.05)。结论 GDM患者的Lp-PLA2活性显著增强,并且与血糖控制水平具有相关性,同时妊娠期血糖控制不良可能导致妊娠不良结局发生率增加。
Objective To explore the change of lipoprotein-pregnancy associated phospholipase A2 (Lp-PLA2) activity in pa- tients with gestational diabetes melfitus (GDM) and its relationship with adverse pregnancy outcome. Methods Sixty-two GDM pregnant women were collected from Obstetric Outpatient in the hospital from September 2012 to January 2014, then they were divided into group A (35 pregnant women with well-controlled blood glucose) and group B (27 pregnant women without good blood glucose control) . Thirty nor- mal pregnant women during the same period were selected as control group. Lp-PLA2 activity and pregnancy outcomes in the three groups were detected and compared. Results There were statistically significant differences in Lp-PLA2 activity, fasting blood glucose (FBG), 2-hour postprandial blood glucose (2 h BG) , insulin resistance index (HOMA-IR) , and tfiglyeeride (TG) levels among the three groups (P〈O. 05) . Lp-PLA2, FBG, 2 h BG, HOMA-IR, and TG levels in group B were statistically significantly higher than those in group A and control group (P〈0. 05) ; Lp-PLA2, FBG, 2 h BG, and HOMA-IR in group A were statistically significantly higher than those in con- trol group ( P〈0.05 ) . The incidence rates of macrosomia, premature rupture of fetal membrane ( PROM), and premature birth in group B were 33.33% , 22. 22% , and 37.04% , respectively, which were statistically significantly higher than those in group A and control group (P〈0. 05) . Among the GDM pregnant women, FBG level was positively correlated with Lp-PLA2 ( P〈0. 05 ) . Conclusion Lp-PLA2 activity increases significantly among GDM patients, which is correlated with the level of blood glucose control; bad blood glucose control during pregnancy may lead to increase of incidence rate of adverse pregnancy outcomes.
出处
《中国妇幼保健》
CAS
2015年第32期5563-5565,共3页
Maternal and Child Health Care of China
基金
山东省医药卫生科技发展计划项目〔BL20130171〕
关键词
妊娠期糖尿病
脂蛋白相关磷脂酶A2
活性
妊娠不良结局
Gestational diabetes mellitus
Lipoprotein associated phospholipase A2
Activity
Adverse pregnancy outcome